Antimicrobial activity and acetylcholinesterase inhibition by extracts from chromatin modulated fungi

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dc.creatorMatheus Thomaz Nogueira Silvalima
dc.creatorLarissa Batista Dos Santos
dc.creatorRafael Wesley Bastos
dc.creatorJacques Robert Nicoli
dc.creatorJacqueline Aparecida Takahashi
dc.date.accessioned2023-10-09T23:19:42Z
dc.date.accessioned2025-09-09T00:58:42Z
dc.date.available2023-10-09T23:19:42Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.bjm.2017.06.004
dc.identifier.issn1517-8382
dc.identifier.urihttps://hdl.handle.net/1843/59344
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Microbiology
dc.rightsAcesso Aberto
dc.subjectFungos
dc.subjectProdutos de ação antimicrobiana
dc.subject.otherAntimicrobial activity
dc.subject.otherAcetylcholinesterase inhibition
dc.subject.otherEpigenetic modulation
dc.subject.otherPenicillium sp.
dc.subject.otherTalaromyces sp.
dc.titleAntimicrobial activity and acetylcholinesterase inhibition by extracts from chromatin modulated fungi
dc.typeArtigo de periódico
local.citation.epage176
local.citation.issue1
local.citation.spage169
local.citation.volume49
local.description.resumoMajor health challenges as the increasing number of cases of infections by antibiotic multiresistant microorganisms and cases of Alzheimer's disease have led to searching new control drugs. The present study aims to verify a new way of obtaining bioactive extracts from filamentous fungi with potential antimicrobial and acetylcholinesterase inhibitory activities, using epigenetic modulation to promote the expression of genes commonly silenced. For such finality, five filamentous fungal species (Talaromyces funiculosus, Talaromyces islandicus, Talaromyces minioluteus, Talaromyces pinophilus, Penicillium janthinellum) were grown or not with DNA methyltransferases inhibitors (procainamide or hydralazine) and/or a histone deacetylase inhibitor (suberohydroxamic acid). Extracts from T. islandicus cultured or not with hydralazine inhibited Listeria monocytogenes growth in 57.66 ± 5.98% and 15.38 ± 1.99%, respectively. Increment in inhibition of acetylcholinesterase activity was observed for the extract from P. janthinellum grown with procainamide (100%), when compared to the control extract (39.62 ± 3.76%). Similarly, inhibition of acetylcholinesterase activity increased from 20.91 ± 3.90% (control) to 92.20 ± 3.72% when the tested extract was obtained from T. pinophilus under a combination of suberohydroxamic acid and procainamide. Concluding, increases in antimicrobial activity and acetylcholinesterase inhibition were observed when fungal extracts in the presence of DNA methyltransferases and/or histone deacetylase modulators were tested.
local.identifier.orcidhttps://orcid.org/0000-0003-4651-3840
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1517838216309339?via%3Dihub

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