Pericyte in oral squamous cell carcinoma: a systematic review

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dc.creatorIsabella Bittencourt do Valle
dc.creatorLauren Frenzel Schuch
dc.creatorJanine Mayra da Silva
dc.creatorAlfonso Gala-García
dc.creatorIvana Márcia Alves Diniz
dc.creatorAlexander Birbrair
dc.creatorLucas Guimarães Abreu
dc.creatorTarcília Aparecida da Silva
dc.date.accessioned2025-08-27T19:57:27Z
dc.date.accessioned2025-09-09T00:30:39Z
dc.date.available2025-08-27T19:57:27Z
dc.date.issued2020-12
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s12105-020-01188-2
dc.identifier.issn1936-0568
dc.identifier.urihttps://hdl.handle.net/1843/84635
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHead and Neck Pathology
dc.rightsAcesso Restrito
dc.subjectMouth neoplasms
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectPericytes
dc.subjectActins
dc.subjectBlood
dc.subjectReceptors, platelet-derived growth factor
dc.subject.otherAlpha-SMA protein
dc.subject.otherNeuron-glial antigen 2
dc.subject.otherOral cancer
dc.subject.otherOral squamous cell carcinoma
dc.subject.otherPericytes
dc.subject.otherPlatelet derived growth factor receptor beta protein
dc.titlePericyte in oral squamous cell carcinoma: a systematic review
dc.typeArtigo de periódico
local.citation.epage1091
local.citation.issue4
local.citation.spage1080
local.citation.volume14
local.description.resumoThe microenvironment of oral cancer is highly dynamic and has been proved to affect tumor progression. Pericytes are blood vessels surrounding cells that have recently gained attention for their roles in vascular and cancer biology. The objective of the present study was to survey the scientific literature for conclusive evidence about whether pericytes are part of blood vessels in oral squamous cell carcinoma (OSCC) and their roles in the tumor microenvironment and clinical outcomes. A systematic electronic search was undertaken in Medline Ovid, PubMed, Web of Science, and Scopus. Eligibility criteria were: publications adopting in vivo models of OSCC that included pericyte detection and assessment by pericyte markers (e.g., α-smooth muscle actin, neuron-glial antigen 2 and platelet-derived growth factor receptor-β). The search yielded seven eligible studies (from 2008 to 2018). The markers most commonly used for pericyte detection were α-smooth muscle actin and neuron-glial antigen 2. The studies reviewed showed the presence of immature vessels exhibiting a reduction of pericyte coverage in OSCC and indicated that anti-cancer therapies could contribute to vessel normalization and pericyte regain. The pericyte population is significantly affected during OSCC development and cancer therapy. While these findings might suggest a role for pericytes in OSCC progression, the limited data available do not allow us to conclude whether they modify the tumor microenvironment and clinical outcome.
local.identifier.orcidhttps://orcid.org/0000-0002-3221-3057
local.identifier.orcidhttps://orcid.org/0000-0002-0993-936X
local.identifier.orcidhttps://orcid.org/0000-0002-1473-7455
local.identifier.orcidhttps://orcid.org/0000-0002-3934-1094
local.identifier.orcidhttps://orcid.org/0000-0003-4261-0037
local.identifier.orcidhttps://orcid.org/0000-0003-1015-2561
local.identifier.orcidhttps://orcid.org/0000-0003-2258-8071
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12105-020-01188-2

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