Comparison of clinical efficacy of pro-argin and novamin toothpastes in relieving dentin hypersensitivity: a systematic review and meta-analysis

dc.creatorDiandra Costa Arantes
dc.creatorFrancisco Ivison Rodrigues Limeira
dc.creatorMonica Yamauti
dc.creatorAllyson Nogueira Moreira
dc.creatorLucas Guimarães Abreu
dc.creatorCláudia Silami Magalhães
dc.date.accessioned2022-08-16T19:11:27Z
dc.date.accessioned2025-09-09T00:52:02Z
dc.date.available2022-08-16T19:11:27Z
dc.date.issued2019
dc.identifier.doi10.3290/j.ohpd.a43272
dc.identifier.issn16021622
dc.identifier.urihttps://hdl.handle.net/1843/44291
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Health & Preventive Dentistry
dc.rightsAcesso Restrito
dc.subjectToothpastes
dc.subjectDentifrices
dc.subjectDentin sensitivity
dc.subjectDentin desensitizing agents
dc.subject.otherPro-argin
dc.subject.otherNovamin
dc.subject.otherToothpastes
dc.subject.otherDentin desensitizing agents
dc.subject.otherDentin hypersensitivity
dc.titleComparison of clinical efficacy of pro-argin and novamin toothpastes in relieving dentin hypersensitivity: a systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.epage412
local.citation.issue5
local.citation.spage403
local.citation.volume17
local.description.resumoPurpose: To compare the clinical efficacy of toothpastes containing Pro-Argin and NovaMin as dentin hypersensitivity (DH) treatment. Materials and Methods: A systematic review and meta-analysis based on PRISMA was conducted (PROSPERO registration CRD42018095367). Electronic searches were performed in Pubmed, Scopus, Cochrane Library, Web of Science, Virtual Health Library and Open Grey until June 2018, with the terms [pro-argin OR arginine] AND [novamin OR calcium sodium phosphosilicate OR calcium sodium phospho silicate]. Randomised and non-randomised clinical trials comparing DH reduction in adults given Pro-argin-containing toothpastes and NovaMin-containing toothpastes were included. Study selection and quality assessment with Cochrane tool were performed. In the meta-analysis, the comparison between desensitising toothpastes was assessed by standardised mean difference (SMD) with 95% confidence intervals (CI). Certainty of evidence was evaluated with GRADE. Results: Five studies fulfilled the inclusion criteria. In four included studies, a reduction in the DH under tactile stimulus between baseline and post-application times for both toothpastes was demonstrated. Three studies were suitable for meta-analysis. No statistically significant difference between the two toothpastes for DH reduction was observed at immediate (SMD = -1.05, CI = -3.52;1.41), 2-week (SMD = -0.55, CI = -2.59;1.48) and 4-week (SMD = -0.49, CI = -2.78;1.81) follow-up. Certainty of the evidence was very low. Included studies presented a high risk of bias. Conclusions: Pro-argin-containing and NovaMin-containing toothpastes showed effectiveness for DH reduction. No statistically significant difference between the two toothpastes was found. Thus, both can be prescribed to treat DH in adults with equivalent effectiveness up to four weeks.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.quintessence-publishing.com/deu/en/article/842236

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