IFITM3 rs12252 polymorphism association with COVID-19 severity and mortality in a Brazilian sample: an update and a meta-analysis

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dc.creatorJoão Araújo
dc.creatorVictoria Bonifacio
dc.creatorLorena Medeiros Batista
dc.creatorRenata de Almeida Marcondes
dc.creatorRenato Santana de Aguiar
dc.creatorLuciana Bastos-Rodrigues
dc.creatorRenan Pedra de Souza
dc.date.accessioned2026-01-06T20:59:27Z
dc.date.issued2024-05-27
dc.identifier.doihttps://doi.org/10.1590/0001-3765202420231160
dc.identifier.issn1678-2690
dc.identifier.urihttps://hdl.handle.net/1843/1296
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnais da Academia Brasileira de Ciências
dc.rightsAcesso aberto
dc.subjectCOVID-19
dc.subject.otherInterferon
dc.subject.otherCOVID-19 prognosis
dc.subject.otherSNP
dc.subject.otherPolymorphisms
dc.subject.otherGenetic association
dc.titleIFITM3 rs12252 polymorphism association with COVID-19 severity and mortality in a Brazilian sample: an update and a meta-analysis
dc.typeArtigo de periódico
local.citation.epage5
local.citation.issue2
local.citation.spage1
local.citation.volume96
local.description.resumoThis study investigated the association between the IFITM3 rs12252 polymorphism and the severity and mortality of COVID-19 in hospitalized Brazilian patients. A total of 102 COVID-19 patients were included, and the outcomes of interest were defined as death and the need for mechanical ventilation. Genotypes were assessed using Taqman probes. No significant associations were found between the rs12252 polymorphism and COVID-19 outcomes in the original sample, both for death and the need for mechanical ventilation. A meta-analysis, incorporating previous studies that used death as a severity indicator, revealed no association in the allelic and C-recessive models. However, due to the rarity of the T allele and its absence in the sample, further replication studies in larger and more diverse populations are needed to clarify the role of rs12252 in COVID-19 prognosis.
local.identifier.orcidhttps://orcid.org/0000-0001-9469-9673
local.identifier.orcidhttps://orcid.org/0009-0002-0882-3354
local.identifier.orcidhttps://orcid.org/0000-0003-0439-4660
local.identifier.orcidhttps://orcid.org/0000-0003-4025-3558
local.identifier.orcidhttps://orcid.org/0000-0001-5180-3717
local.identifier.orcidhttps://orcid.org/0000-0002-9053-7201
local.identifier.orcidhttps://orcid.org/0000-0002-9479-4432
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.subject.cnpqCIENCIAS BIOLOGICAS::GENETICA
local.url.externahttps://www.scielo.br/j/aabc/a/VGxmMwKbLjPqLkMnVDJ3pbq/?lang=en

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