Spontaneously hypertensive rats have greater impairments in regulating abdominal temperature than brain cortex temperature following physical exercise

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dc.creatorLucas Rios Drummond
dc.creatorThales Nicolau Primola Gomes
dc.creatorAna Cançado Kunstetter
dc.creatorHelton Oliveira Campos
dc.creatorFilipe Ferreira Vaz
dc.creatorFilipe Rios Drummond
dc.creatorAndré Gustavo Pereira de Andrade
dc.creatorCândido Celso Coimbra
dc.creatorAntônio José Natali
dc.creatorSamuel Penna Wanner
dc.date.accessioned2022-06-07T17:49:54Z
dc.date.accessioned2025-09-09T00:37:19Z
dc.date.available2022-06-07T17:49:54Z
dc.date.issued2019-07
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.jtherbio.2019.04.011
dc.identifier.issn0306-4565
dc.identifier.urihttps://hdl.handle.net/1843/42327
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Thermal Biology
dc.rightsAcesso Restrito
dc.subjectHipertensão
dc.subjectHipertermia
dc.subjectExercícios físicos
dc.subjectCorpo - Temperatura - Regulação
dc.subjectTemperatura atmosférica
dc.subjectTemperatura corporal
dc.subject.otherHypertension
dc.subject.otherHyperthermia
dc.subject.otherPost-exercise
dc.subject.otherRecovery
dc.subject.otherThermoregulation
dc.subject.otherWarm environment
dc.titleSpontaneously hypertensive rats have greater impairments in regulating abdominal temperature than brain cortex temperature following physical exercise
dc.typeArtigo de periódico
local.citation.epage36
local.citation.spage30
local.citation.volume83
local.description.resumoThis study aimed to evaluate the changes in brain (Tbrain) and abdominal (Tabd) temperatures in spontaneously hypertensive rats (SHRs) following fatiguing exercise. Male normotensive Wistar rats (NWRs) and SHRs were used at 16 weeks of age. Their arterial pressure was measured by tail plethysmography prior to the experiments to confirm the hypertensive status of the SHRs. Then, the rats underwent implantation of an abdominal temperature sensor to measure Tabd and a guide cannula in the frontal cortex to enable the insertion of a thermistor to measure Tbrain. After a familiarization period, each animal was subjected to incremental speed exercises until fatigue in either a temperate (25 °C) or warm (32 °C) environment, followed by a 60-min post-exercise period at the same temperature at which they exercised. Tbrain, Tabd and tail-skin temperature (Tskin) were measured every min throughout the experiments. SHRs exhibited higher Tabd values than NWRs, and these higher values were transiently and persistently observed at 25 °C and 32 °C, respectively. For example, at 32 °C, Tabd was 0.84 °C higher in SHRs at the 25th min (large effect size). In contrast, regardless of the ambient temperature, SHRs exhibited similar Tbrain values as NWRs, indicating preserved Tbrain regulation following exercise in hypertensive rats. SHRs presented higher Tskin during the last half of the post-exercise period at 25 °C, whereas no inter-group differences were observed at 32 °C. In conclusion, the present results highlight that SHRs, an animal model that mimics uncontrolled essential hypertension in humans, exhibited greater impairments in regulating Tabd than Tbrain during the post-exercise period.
local.identifier.orcidhttp://orcid.org/0000-0002-6042-7757
local.identifier.orcidhttp://orcid.org/0000-0002-4001-4429
local.identifier.orcidhttps://orcid.org/ 0000-0001-5720-8054
local.identifier.orcidhttps://orcid.org/ 0000-0002-6043-9256
local.identifier.orcidhttps://orcid.org/ 0000-0003-3406-4558
local.identifier.orcidhttps://orcid.org/0000-0001-8981-6724
local.identifier.orcidhttps://orcid.org/ 0000-0002-4927-4024
local.identifier.orcidhttp://orcid.org/0000-0002-4659-1032
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0306456519300403?via%3Dihub

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