Tissue factor-dependent pathway in severe preeclampsia revisited: a Brazilian cohort study

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dc.creatorLuci Maria SantAna Dusse
dc.creatorLara Carvalho Godoi
dc.creatorKarina Braga Gomes Borges
dc.creatorMaria das Graças Carvalho
dc.creatorBashir Abdulgader Lwaleed
dc.date.accessioned2022-03-16T14:00:02Z
dc.date.accessioned2025-09-08T23:49:06Z
dc.date.available2022-03-16T14:00:02Z
dc.date.issued2016-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doi10.1097/MBC.0000000000000507
dc.identifier.issn1473-5733
dc.identifier.urihttps://hdl.handle.net/1843/40147
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBlood Coagulation and Fibrinolysis
dc.rightsAcesso Restrito
dc.subjectSangue
dc.subjectFator VII
dc.subjectFator VIIa
dc.subjectPlasma
dc.subjectPré-eclâmpsia
dc.subjectComplicações na gravidez
dc.subjectTromboplastina
dc.subject.otherBlood
dc.subject.otherFactor VII
dc.subject.otherFactor VIIa
dc.subject.otherPlasma
dc.subject.otherPreeclampsia
dc.subject.otherPregnancy complications
dc.subject.otherTissue factor
dc.subject.otherTissue factor pathway inhibitor
dc.titleTissue factor-dependent pathway in severe preeclampsia revisited: a Brazilian cohort study
dc.typeArtigo de periódico
local.citation.epage440
local.citation.issue4
local.citation.spage436
local.citation.volume27
local.description.resumoPreviously we investigated the tissue factor (TF)-dependent coagulation pathway and key haemostatic cofactors in white women with preeclampsia (P-EC) and suggested that plasma factor VII (FVII) levels can differentiate women with P-EC from healthy nonpregnant women or normal pregnant women, at the same trimester, with high sensitivity, specificity, positive and negative predictive values. Here we re-examine the TF-dependent pathway in a large cohort of Brazilian women. A total of 240 women were studied. These included healthy nonpregnant women (n = 79), normotensive pregnant women (n = 80) and women with severe P-EC (n = 81). Commercially available enzyme-linked immunosorbent assays were used to measure plasma FVII, activated factor VII (FVIIa), TF and tissue factor pathway inhibitor (TFPI). All study participants were matched for age. Pregnant women (with/without P-EC) were matched for gestational age and parity. Plasma levels of FVII, FVIIa and TFPI were significantly increased in women with severe P-EC compared with healthy nonpregnant women (P < 0.01) or normotensive pregnant women (P < 0.01). FVIIa was also higher in normotensive pregnant women compared with nonpregnant women (P < 0.01). However, no such significant trends were observed for plasma TF levels (P = 0.074). In conclusion, circulating FVII, FVIIa and TFPI were significantly elevated in women with severe P-EC in the absence of comparable changes in plasma TF levels. The present work is in agreement with our previous report on FVII levels in white women with P-EC. Thus, this lends further support to the notion that plasma FVII levels are potentially valuable diagnostic marker for P-EC, irrespective of ethnicity.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/bloodcoagulation/Abstract/2016/06000/Tissue_factor_dependent_pathway_in_severe.14.aspx

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