Rate of polymyxin resistance among Acinetobacter baumannii recovered from hospitalized patients: a systematic review and meta-analysis

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dc.creatorWilliam Gustavo Lima
dc.creatorJúlio César Moreira Brito
dc.creatorBárbara Gatti Cardoso
dc.creatorValbert Nascimento Cardoso
dc.creatorMagna Cristina de Paiva
dc.creatorMaria Elena de Lima
dc.creatorSimone Odília Antunes Fernandes
dc.date.accessioned2022-05-24T21:50:42Z
dc.date.accessioned2025-09-08T23:44:16Z
dc.date.available2022-05-24T21:50:42Z
dc.date.issued2020
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1007/s10096-020-03876-x
dc.identifier.issn0934-9723
dc.identifier.urihttps://hdl.handle.net/1843/41938
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseases
dc.rightsAcesso Restrito
dc.subjectPolimixinas
dc.subjectAcinetobacter baumannii
dc.subjectPacientes
dc.subjectRevisão sistemática
dc.subjectMetanálise
dc.subject.otherAcinetobacter baumannii
dc.subject.otherCarbapenem resistant
dc.subject.otherColistin
dc.subject.otherHospital infections
dc.subject.otherPolymyxin B.
dc.titleRate of polymyxin resistance among Acinetobacter baumannii recovered from hospitalized patients: a systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.epage1438
local.citation.issue8
local.citation.spage1427
local.citation.volume39
local.description.resumoWe conducted a systematic review and meta-analysis to determine the rate of polymyxin resistance among Acinetobacter baumannii isolates causing infection in hospitalized patients around the world during the period of 2010-2019. The systematic review was performed on September 1, 2019, using PubMed/MEDLINE, Scopus, and Web of Science; studies published after January 1, 2010, were selected. The data were summarized in tables, critically analyzed, and treated statistically using the RStudio® Software with Meta package and Metaprop Command. After applying exclusion factors, 41 relevant studies were selected from 969 articles identified on literature search. The overall rate of polymyxin-resistant A. baumannii (PRAB) related to hospitalized patients was estimated to be 13% (95% CI, 0.06-0.27), where a higher rate was observed in America (29%; 95% CI, 0.12-0.55), followed by Europe (13%; 95% CI, 0.02-0.52), and Asia (10%; 95% CI, 0.02-0.32). The extensive use of polymyxins on veterinary to control bacterial infection and growth promotion, as well as the resurgence in prescription and use of polymyxins in the clinics against carbapenem-resistant gram-negative bacteria, may have contributed to the increased incidence of PRAB. The findings of this meta-analysis revealed that the rate of PRAB recovered from hospitalized patients is distinctively high. Thus, action needs to be taken to develop strategies to combat the clinical incidence of PRAB-induced hospital infections.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10096-020-03876-x

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