Neuroserpin: a potential biomarker for early-onset severe preeclampsia

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dc.creatorLuiza Oliveira Perucci
dc.creatorSirlaine Pio Gomes da Silva
dc.creatorEduardo Bearzoti
dc.creatorKelerson Mauro de Castro Pinto
dc.creatorPatrícia Nessralla Alpoim
dc.creatorMelina de Barros Pinheiro
dc.creatorLara Carvalho Godoi
dc.creatorLauro Ângelo Gonçalves de Moraes
dc.creatorLirlândia Pires de Sousa
dc.creatorLuci Maria Sant`Ana Dusse
dc.creatorAndré Talvani
dc.date.accessioned2024-11-26T23:05:28Z
dc.date.accessioned2025-09-08T23:06:52Z
dc.date.available2024-11-26T23:05:28Z
dc.date.issued2023-03
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doi10.1016/j.imbio.2023.152339
dc.identifier.issn0171-2985
dc.identifier.urihttps://hdl.handle.net/1843/78302
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofImmunobiology
dc.rightsAcesso Restrito
dc.subjectPré-eclâmpsia
dc.subjectBiomarcador
dc.subject.otherNeuroserpina
dc.subject.otherInflamação
dc.subject.otherPré-eclâmpsia
dc.subject.otherBiomarcador
dc.titleNeuroserpin: a potential biomarker for early-onset severe preeclampsia
dc.typeArtigo de periódico
local.citation.epage9
local.citation.issue2
local.citation.spage1
local.citation.volume228
local.description.resumoAbstract Preeclampsia is a hypertensive disease of pregnancy associated with intense inflammatory and pro-coagulant responses. Neuroserpin is a serine protease inhibitor that has been involved in neurological and immune processes and has not yet been investigated in preeclampsia. Herein, we evaluated neuroserpin levels in association with other inflammatory mediators (IL-17A, IL-33, and CXCL-16) during severe preeclampsia. The mediators’ plasma levels were measured by immunoassays in 24 pregnant women with severe preeclampsia (early preeclampsia: N = 17, late preeclampsia: N = 7), 34 normotensive pregnant women, and 32 non-pregnant women. In general, pregnancy was associated with higher levels of neuroserpin, IL-17A, IL-33, and CXCL-16 than the non-pregnant state. However, this increase was attenuated in pregnancies complicated by severe preeclampsia. Although neuroserpin levels did not differ between normotensive pregnant women and pregnant women with severe preeclampsia, neuroserpin levels tended to be lower in early-onset than in late-onset severe preeclampsia. There were positive correlations between neuroserpin and IL-17A, neuroserpin and CXCL-16, and IL-17A and CXCL-16 levels in women with severe preeclampsia. In addition, although the risk for developing severe preeclampsia was higher in older women in this study, maternal age did not significantly influence the mediators’ levels, nor their correlations in the preeclampsia group. In summary, our data suggest that neuroserpin might be a potential biomarker for early-onset severe preeclampsia and, that the imbalance among neuroserpin, IL-17A, IL-33, and CXCL-16 levels may be associated with the pathogenesis of preeclampsia, regardless of the maternal age.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0171298523000074?via%3Dihub

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