Lessons from a multilaboratorial task force for diagnosis of a fatal toxoplasmosis outbreak in captive primates in Brazil

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dc.creatorFrancine Bittencourt Schiffler
dc.creatorThamiris dos Santos Miranda
dc.creatorMatheus Augusto Calvano Cosentino
dc.creatorRenata Carvalho de Oliveira
dc.creatorJorlan Fernandes
dc.creatorMatheus Ribeiro da Silva Assis
dc.creatorJonathan Gonçalves de Oliveira
dc.creatorThayssa Alves Coelho da Silva
dc.creatorRafael Mello Galliez
dc.creatorDebora Souza Faffe
dc.creatorJaqueline Goes de Jesus
dc.creatorAsheley Henrique Barbosa Pereira
dc.creatorRenato Santana de Aguiar
dc.creatorSilvia Bahadian Moreira
dc.creatorIgor Falco Arruda
dc.creatorFilipe Romero Rebello Moreira
dc.creatorMirela D'arc
dc.creatorIngra Morales Claro
dc.creatorThalita de Abreu Pissinatti
dc.creatorLiliane Tavares de Faria Cavalcante
dc.creatorAmilcar Tanuri
dc.creatorEster Cerdeira Sabino
dc.creatorAndre Santos
dc.date.accessioned2025-01-23T21:27:34Z
dc.date.accessioned2025-09-09T00:32:30Z
dc.date.available2025-01-23T21:27:34Z
dc.date.issued2023-11-29
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/microorganisms11122888
dc.identifier.issn2076-2607
dc.identifier.urihttps://hdl.handle.net/1843/79446
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMicroorganisms
dc.rightsAcesso Aberto
dc.subjectToxoplasmose
dc.subjectPatologia veterinária
dc.subjectSaúde pública
dc.subjectPolítica pública
dc.subject.otherPublic policy
dc.subject.otherParasitic infection
dc.subject.otherToxoplasmosis
dc.subject.otherNeotropical primate
dc.subject.otherOne health
dc.subject.otherVeterinary pathology
dc.titleLessons from a multilaboratorial task force for diagnosis of a fatal toxoplasmosis outbreak in captive primates in Brazil
dc.typeArtigo de periódico
local.citation.epage21
local.citation.issue12
local.citation.spage1
local.citation.volume11
local.description.resumooxoplasmosis is an important zoonotic disease caused by the parasite Toxoplasma gondii and is especially fatal for neotropical primates. In Brazil, the Ministry of Health is responsible for national epizootic surveillance, but some diseases are still neglected. Here, we present an integrated investigation of an outbreak that occurred during the first year of the COVID-19 pandemic among eleven neotropical primates housed at a primatology center in Brazil. After presenting non-specific clinical signs, all animals died within four days. A wide range of pathogens were evaluated, and we successfully identified T. gondii as the causative agent within four days after necropsies. The liver was the most affected organ, presenting hemorrhage and hepatocellular necrosis. Tachyzoites and bradyzoite cysts were observed in histological examinations and immunohistochemistry in different organs; in addition, parasitic DNA was detected through PCR in blood samples from all specimens evaluated. A high prevalence of Escherichia coli was also observed, indicating sepsis. This case highlights some of the obstacles faced by the current Brazilian surveillance system. A diagnosis was obtained through the integrated action of researchers since investigation for toxoplasmosis is currently absent in national guidelines. An interdisciplinary investigation could be a possible model for future epizootic investigations in animals.
local.identifier.orcidhttps://orcid.org/0000-0002-5039-0604
local.identifier.orcidhttps://orcid.org/0000-0002-5404-272X
local.identifier.orcidhttps://orcid.org/0000-0001-9704-9801
local.identifier.orcidhttps://orcid.org/0000-0001-5180-3717
local.identifier.orcidhttps://orcid.org/0000-0003-3644-0246
local.identifier.orcidhttps://orcid.org/0000-0003-1925-5305
local.identifier.orcidhttps://orcid.org/0000-0001-6973-7068
local.identifier.orcidhttps://orcid.org/0000-0002-4808-8158
local.identifier.orcidhttps://orcid.org/0000-0002-0481-4373
local.identifier.orcidhttps://orcid.org/0000-0002-7162-5070
local.identifier.orcidhttps://orcid.org/0000-0003-0570-750X
local.identifier.orcidhttps://orcid.org/0000-0003-2623-5126
local.identifier.orcidhttps://orcid.org/0000-0003-3372-1552
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE ZOOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2076-2607/11/12/2888

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