Gallic acid has an inhibitory effect on skin squamous cell carcinoma and acts on the heat shock protein HSP90AB1

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dc.creatorSabrina Ferreira de Jesus
dc.creatorMarcela Gonçalves de Souza
dc.creatorLorena dos Reis Pereira Queiroz
dc.creatorDaniela Paola Santos de Paula
dc.creatorAngeliny Tamiarana Lima Tabosa
dc.creatorWislene Sarajane Moreira Alves
dc.creatorLuiz Henrique da Silveira
dc.creatorAndré Teixeira da Silva Ferreira
dc.creatorOzires José Dutra Martuscelli
dc.creatorLucyana Conceição Farias
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2024-10-09T19:16:10Z
dc.date.accessioned2025-09-09T01:32:22Z
dc.date.available2024-10-09T19:16:10Z
dc.date.issued2023-01-30
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.gene.2022.147041
dc.identifier.issn1879-0038
dc.identifier.urihttps://hdl.handle.net/1843/77342
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofGene
dc.rightsAcesso Aberto
dc.subjectPele - Câncer
dc.subjectCarcinoma de células escamosas
dc.subjectMetástase
dc.subjectÁcido gálico
dc.subjectBioinformática
dc.titleGallic acid has an inhibitory effect on skin squamous cell carcinoma and acts on the heat shock protein HSP90AB1
dc.typeArtigo de periódico
local.citation.spage147041
local.citation.volume851
local.description.resumoDifferences in the features of aggressiveness of non-melanoma skin cancer (NMSC) subtypes, between basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are relevant characteristics. Comparing the characteristics between NMSC subtypes might help identify molecules associated with cancer metastasis and invasion. Considering these facts, the current study aimed to identify a molecular target for inhibiting skin cancer metastasis and invasion. Proteomic analysis suggested that heat shock protein 90 kDa, alpha, class B member 1 (HSP90AB1), pentaxin (PTX3), caspase-14 (CASP14), S100, actin-1, and profilin were the primary targets related to metastasis and invasion. However, after a differential expression comparison between BCC and SCC, HSP90AB1 was identified as the best target to repress metastasis and invasion. Based on molecular docking results, gallic acid (GA) was selected to inhibit HSP90AB1. A specific Hsp90ab1 siRNA targeting was designed and compared to GA. Interestingly, GA was more efficient in silencing HSP90AB1 than siRNAhsp90ab1. Hence, our data suggest that HSP90AB1 is a crucial biomarker for identifying invasion and metastasis and that its inhibition may be a viable strategy for treating skin cancer.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0378111922008617?via%3Dihub

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