Oral probiotic Bifidobacterium longum supplementation improves metabolic parameters and alters the expression of the renin-angiotensin system in obese mice liver

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dc.creatorAmanda Souto Machado
dc.creatorJanaína Ribeiro Oliveira
dc.creatorDeborah de Farias Lelis
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorIgor Viana Brandi
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2022-09-06T14:24:22Z
dc.date.accessioned2025-09-09T00:59:31Z
dc.date.available2022-09-06T14:24:22Z
dc.date.issued2020-07-23
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1177/1099800420942942
dc.identifier.issn1552-4175
dc.identifier.urihttps://hdl.handle.net/1843/44950
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiological Research for Nursing
dc.rightsAcesso Aberto
dc.subjectSistema renina-angiotensina
dc.subjectObesidade
dc.subjectFígado - Doenças
dc.subjectTecido adiposo
dc.titleOral probiotic Bifidobacterium longum supplementation improves metabolic parameters and alters the expression of the renin-angiotensin system in obese mice liver
dc.typeArtigo de periódico
local.citation.epage108
local.citation.issue1
local.citation.spage100
local.citation.volume23
local.description.resumoBackground: obesity and non-alcoholic fatty liver disease (NAFLD) have been increasing at an alarming rate worldwide. Bifidobacterium longum (BL), a common member of the human gut microbiota, has important health benefits through several mechanisms. Objectives: we evaluated the BL supplementation effects on body metabolism and renin-angiotensin components hepatic expression in mice fed a high-fat diet. Methods: thirty-two male mice were divided into four groups: standard diet + placebo (ST), standard diet + Bifidobacterium longum (ST + BL), high-fat diet + placebo (HFD) and high-fat diet + Bifidobacterium longum (HFD + BL). Following the obesity induction period, the ST + BL and HFD + BL groups were supplemented with Bifidobacterium longum for 4 weeks. Then, body, biochemical, histological and molecular parameters were evaluated. Results: HFD + BL mice had a significant decrease in adipose tissue mass and blood glucose levels, as well as a significant reduction in blood glucose during an intraperitoneal glucose tolerance test. The treatment also resulted in reduced levels of total cholesterol and hepatic fat accumulation. Moreover, we observed an increase in angiotensin converting enzyme 2 (ACE2) and Mas receptor (MASR) expression levels in BL-treated obese mice. Conclusions: these data demonstrate that BL may have the potential to prevent obesity and NAFLD by modulating the mRNA expression of renin-angiotensin system components.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/full/10.1177/1099800420942942

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