Versatility of guanidoacetic acid coordination modes and synthesis of its new zinc complex

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dc.creatorJussara Lopes de Miranda
dc.creatorBernardo Lages Rodrigues
dc.creatorLuiza Cristina de Moura
dc.creatorGuilherme Sales da Rocha
dc.creatorSuzane de Sant'Ana Oliveira
dc.date.accessioned2024-11-28T14:39:37Z
dc.date.accessioned2025-09-08T23:11:06Z
dc.date.available2024-11-28T14:39:37Z
dc.date.issued2023
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.rechem.2023.100785
dc.identifier.issn2211-7156
dc.identifier.urihttps://hdl.handle.net/1843/78348
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofResults in Chemistry
dc.rightsAcesso Aberto
dc.subjectAminoacidos - Metabolismo
dc.subjectCompostos de zinco
dc.subjectCompostos de cobre
dc.subjectFourier, Espectroscopia de infravermelho por transformada de
dc.subjectBioquímica
dc.subjectRaios X - Difração
dc.subject.otherGuanidinoacetic acid
dc.subject.otherZinc
dc.subject.otherCopper(II)
dc.titleVersatility of guanidoacetic acid coordination modes and synthesis of its new zinc complex
dc.typeArtigo de periódico
local.citation.spage100785
local.citation.volume5
local.description.resumoGuanidinoacetic acid (GAA) is an amino acid involved in several biological processes including renal activity since it is synthesized mainly in the kidneys, insulin metabolism, creatine/phosphocreatine synthesis and recently as experimental nutrient for multiple sclerosis treatment. Given its biological role, some interactions between GAA and its complexation with essential and toxic metal ions have been previously investigated, both in aqueous medium with Ni(II), Co(II), Cu(II), Zn(II), Cd(II), and Pb(II), as well as in the synthesis of complexes in solid phase. This study presents the versatile coordination modes of GAA and reports its novel solid zinc complex. GAA complexation ranges from the usual α-nitrogen and oxygen bidentate coordination to a paddlewheel monodentate-oxygen mode in a Cu2GAA4 complex. The novel solid GAA zinc complex has only been succeeded to be synthesized in the presence of copper(II) salt, being characterized by single-crystal structure refinement using X-ray diffraction and mid and far-Fourier Transform Infrared spectroscopy. The results showed that the synthesized complex, (HGAA)[Zn(GAA)Cl3].H2O (1) , exhibits a tetrahedral geometry with an oxygen-carboxylate GAA monodentate coordination complemented by three chloride ligands and a water bridge linked to a monoprotonated GAA species. Hydrogen bonds play a crucial role in the stabilization of 1, especially between Zn(GAA)Cl3- and its cation ion, HGAA+. Infrared spectroscopy of 1 presented a band at 412 cm-1 and three bands at 291, 273 and 239 cm-1, corresponding to Zn-O and Zn-Cl stretching modes, respectively. The different coordination modes of guanidinoacetate ion and its complexation with zinc and copper(II), as well as the way the hydrogen bonds stabilize their structures may help to further understand the diverse biochemical processes involved in this amino acid.
local.identifier.orcidhttps://orcid.org/0000-0001-5800-2752
local.identifier.orcidhttps://orcid.org/0000-0003-0586-5639
local.identifier.orcidhttps://orcid.org/0000-0002-1853-4794
local.identifier.orcidhttps://orcid.org/0000-0002-7284-358X
local.identifier.orcidhttps://orcid.org/0000-0003-4139-4870
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2211715623000243?via%3Dihub

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