Reduced functional capacity in patients with chagas disease: a systematic review with meta-analysis

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dc.creatorHenrique Silveira Costa
dc.creatorMárcia Maria Oliveira Lima
dc.creatorFábio Silva Martins da Costa
dc.creatorAna Thereza Chaves
dc.creatorMaria Carmo Pereira Nunes
dc.creatorPedro Henrique Scheidt Figueiredo
dc.creatorManoel Otávio da Costa Rocha
dc.date.accessioned2024-01-09T22:43:29Z
dc.date.accessioned2025-09-09T01:33:18Z
dc.date.available2024-01-09T22:43:29Z
dc.date.issued2018
dc.format.mimetypepdf
dc.identifier.doi10.1590/0037-8682-0158-2018
dc.identifier.issn00378682
dc.identifier.urihttps://hdl.handle.net/1843/62531
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical
dc.rightsAcesso Aberto
dc.subjectChagas disease
dc.subjectFunctional Residual Capacity
dc.subjectExercise Test
dc.subjectSystematic Review
dc.subject.otherChagas disease
dc.subject.otherFunctional Residual Capacity
dc.subject.otherExercise Test
dc.subject.otherSystematic Review
dc.titleReduced functional capacity in patients with chagas disease: a systematic review with meta-analysis
dc.typeArtigo de periódico
local.citation.epage426
local.citation.issue4
local.citation.spage421
local.citation.volume51
local.description.resumoin which functional impairment is detectable remains uncertain. The present study compared functional capacity between healthy controls and patients with different clinical forms of Chagas disease. A systematic review and meta-analysis (PROSPERO database CRD42017058353) was conducted following a search of the MEDLINE, Web of Science, CINAHL, and LILACS databases from September to December 2017 for articles published in English, Spanish, or Portuguese, with no date restrictions. We included studies that compared the VO2peak between healthy and Chagas disease patients, stratified according to 3 clinical forms [no apparent cardiac disease, non-dilated Chagas heart disease (CHD), and dilated CHD]. Seven cross-sectional studies were included. Chagas disease patients without apparent cardiac disease (n=208) had VO2 peak values [mean difference, -1.55ml/kg/min; 95% confidence interval (CI), -4.98ml/kg/min to 1.88ml/kg/min] similar to those of healthy controls (n=105; p=0.38, I2=52%). In non-dilated CHD (n=159), VO2peak was 8.71ml/kg/min lower (95% CI, -13.99 to -3.42ml/kg/min) than in healthy controls (n=59; p=0.001, I2=75%). VO2 peak was also significantly lower (mean difference, -9.30ml/kg/min; 95% CI, -11.34 to -7.25ml/kg/min) in dilated CHD patients (n=131) than in healthy controls (n=53; p<0.001, I2=0%). Exercise capacity in Chagas disease patients without apparent cardiac disease is similar to that in healthy controls. Functional impairment in Chagas disease is detectable in the early stages of cardiac involvement, even in the absence of systolic dysfunction and signs of heart failure.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/0037-8682-0158-2018

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