L-type voltage-dependent Ca2+ channels expression involved in pre-neoplastic transformation of breast cancer

Página do item simplificado
dc.creatorFlávia Aguiar
dc.creatorPaula Rhana Queiroz Araújo
dc.creatorEnrrico Bloise
dc.creatorAndreia Laura Prates Rodrigues
dc.creatorEnio Ferreira
dc.date.accessioned2023-11-06T20:30:27Z
dc.date.accessioned2025-09-08T23:08:00Z
dc.date.available2023-11-06T20:30:27Z
dc.date.issued2022-08-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1186/s42047-022-00117-7
dc.identifier.issn2520-8454
dc.identifier.urihttps://hdl.handle.net/1843/60509
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofSurgical and Experimental Pathology
dc.rightsAcesso Aberto
dc.subjectNeoplasias da Mama
dc.subjectHiperplasia
dc.subjectCarcinoma in situ
dc.subject.otherBreast cancer
dc.subject.otherDuctal hyperplasia
dc.subject.otherCarcinoma in situ
dc.subject.otherL-type voltage-dependent Ca2+ channel
dc.subject.otherLTCC
dc.subject.otherNeoplastic transformation
dc.titleL-type voltage-dependent Ca2+ channels expression involved in pre-neoplastic transformation of breast cancer
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue1
local.citation.spage16
local.citation.volume5
local.description.resumoBackground Intracellular Ca2+ levels can modulate several cellular functions, including proliferation and other processes found altered in neoplastic cells. Helping to maintain Ca2+ homeostasis, L-type voltage-dependent Ca2+ channels had its expression identified in neoplasias, including breast cancer. Invasive breast carcinoma of no special type, the most common classification of breast cancer, has ductal hyperplasia and ductal carcinoma in situ as its possible non-obligate precursors. This channel’s role in breast cancer development from these precursors has not been investigated. Evaluate protein expression and subcellular localization of CaV1.1, CaV1.2, and CaV1.3 in mammary epithelium without alteration and neoplastic and non-neoplastic ductal proliferative lesions through immunohistochemistry was the aim of this investigation. Methods In the present study, CaV1.1, CaV1.2, and CaV1.3 protein expression was evaluated by immunohistochemistry in breast without alteration and in proliferative non-neoplastic and neoplastic ductal epithelial lesions of the human breast. Results It was observed that CaV1.3 presented a reduction in nuclear expression at neoplastic lesions, in addition to an increase in cytoplasmic CaV1.1 expression. The analyses of membrane immunostaining showed that CaV1.2 and CaV1.3 had an increase of expression as the lesions progressed in the stages leading to invasive carcinomas. Conclusions Changes in protein expression and subcellular localization of these channels during the progression stages indicate that they may be involved in neoplastic transformation.
local.identifier.orcidhttp://orcid.org/0000-0002-1835-0303
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://surgexppathol.biomedcentral.com/articles/10.1186/s42047-022-00117-7

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
L-type voltage-dependent Ca2+ channels expression involved in pre-neoplastic transformation of breast cancer.pdf
Tamanho:
937.1 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG