Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a brazilian cohort: comparison with intergrowth

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dc.creatorViviane Cunhacardoso
dc.creatorNathalia Moura de Mello e Silva
dc.creatorFernanda Pegoraro de Godoi Melo
dc.creatorPaulyne Stadler Venzon
dc.creatorDafne Barcala Gomez
dc.creatorMarynéa Silva do Vale
dc.creatorMaria Regina Bentlin
dc.creatorMarina Carvalho de Moraes Barros
dc.creatorLaura Emilia Monteiro Bigélli Cardoso
dc.creatorEdna Maria de Albuquerque Diniz
dc.creatorJorge Hecker Luz
dc.creatorCarlos Grandi
dc.creatorSérgio Tadeu Martins Marba
dc.creatorJoão Henrique Carvalho Leme de Almeida
dc.creatorDavi Casale Aragon
dc.creatorFabio Carmona
dc.creatorRita c. Silveira
dc.creatorJosé Luiz Bandeira Duarte
dc.creatorMaria Cândida Ferrarez Bouzada Viana
dc.creatorDaniela Marques de Lima Mota Ferreira
dc.creatorJosé Mariano Sales Alves
dc.creatorLaís Furlan Embrizi
dc.creatorCarolina Boschi Gimenes
dc.date.accessioned2025-08-07T19:51:55Z
dc.date.accessioned2025-09-09T01:21:28Z
dc.date.available2025-08-07T19:51:55Z
dc.date.issued2023
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.jped.2022.07.007
dc.identifier.issn00217557
dc.identifier.urihttps://hdl.handle.net/1843/84186
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Aberto
dc.subjectPremature Birth
dc.subjectInfant, Very Low Birth Weight
dc.subjectPhenotype
dc.subjectPredictive Value of Tests
dc.subject.otherPremature birth
dc.subject.otherVery low birth weigh
dc.subject.otherPhenotype
dc.subject.otheroutcome
dc.subject.otherPredictive values
dc.subject.otherNetwork
dc.titleGrowth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a brazilian cohort: comparison with intergrowth
dc.typeArtigo de periódico
local.citation.epage93
local.citation.issue1
local.citation.spage86
local.citation.volume99
local.description.resumoObjective: To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21).Methods: Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21.Results: 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value.Conclusion: The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1016/j.jped.2022.07.007

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