Dexamethasone abrogates the antimicrobial and antibiofilm activities of different drugs against clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa

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dc.creatorÁquila Rodrigues
dc.creatorAndre Gomes
dc.creatorPedro Henrique Ferreira Marçal
dc.creatorMarcus Vinícius Dias-Souza
dc.date.accessioned2024-09-25T21:58:29Z
dc.date.accessioned2025-09-08T23:59:17Z
dc.date.available2024-09-25T21:58:29Z
dc.date.issued2017
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.jare.2016.12.001
dc.identifier.issn2090-1224
dc.identifier.urihttps://hdl.handle.net/1843/76902
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Advanced Research
dc.rightsAcesso Aberto
dc.subjectDexametasona
dc.subjectAnti-Infecciosos
dc.subjectStaphylococcus aureus
dc.subjectPseudomonas aeruginosa
dc.titleDexamethasone abrogates the antimicrobial and antibiofilm activities of different drugs against clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa
dc.typeArtigo de periódico
local.citation.epage61
local.citation.issue1
local.citation.spage55
local.citation.volume8
local.description.resumoStaphylococcus aureus and Pseudomonas aeruginosa are part of the human microbiota and are also important bacterial pathogens, for which therapeutic options are lacking nowadays. The combined administration of corticosteroids and antimicrobials is commonly used in the treatment of infectious diseases to control inflammatory processes and to minimize potential toxicity of antimicrobials, avoiding sequelae. Although different pharmaceutical dosage forms of antimicrobials combined to corticosteroids are available, studies on the interference of corticosteroids on the pharmacological activity of antimicrobials are scarce and controversial. Here, we provide evidence of the interference of dexamethasone on the pharmacological activity of clinically important antimicrobial drugs against biofilms and planktonic cells of S. aureus and P. aeruginosa. Broth microdilution assays of minimal inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum biofilm eradication concentration (MBEC) of gentamicin, chloramphenicol, oxacillin, ceftriaxone and meropenem were conducted with and without the addition of dexamethasone. The effect of all drugs was abrogated by dexamethasone in their MIC, MBC, and MBEC, except gentamicin and meropenem, for which the MBC was not affected in some strains. The present study opens doors for more investigations on in vitro and in vivo effects and safety of the combination of antimicrobials and glucocorticoids.
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198789/

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