Interaction of Pseudobombax marginatum robyns stem bark extract on the cell surface of Bacillus cereus and Staphylococcus aureus

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dc.creatorElizabeth Cristina Gomes dos Santos
dc.creatorLuis Marcos Farias
dc.creatorFrancisco Humberto Xavier Junior
dc.creatorGabriel Araujo da Silva
dc.creatorEduardo Roberto Silva Camargos
dc.creatorMaria Gonçalves Almeida
dc.creatorMaria Auxiliadora Roque de Carvalho
dc.creatorLarissa Alves Correa
dc.creatorClaudio Luis Donnici
dc.date.accessioned2025-01-29T16:20:03Z
dc.date.accessioned2025-09-08T22:50:05Z
dc.date.available2025-01-29T16:20:03Z
dc.date.issued2018
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.issn2471-0172
dc.identifier.urihttps://hdl.handle.net/1843/79526
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Bacteriology and Mycology
dc.rightsAcesso Aberto
dc.subjectAgentes antibacterianos
dc.subjectMecanismo de ação (Bioquímica)
dc.subjectMicroscopia eletrônica
dc.subjectFenóis
dc.subjectMatéria médica vegetal
dc.subjectCitotoxidade de mediação celular
dc.subjectProdutos de ação antimicrobiana
dc.subject.otherPseudobombax marginatum
dc.subject.otherMalvaceae
dc.subject.otherAntibacterial activity
dc.subject.otherMechanism of action
dc.subject.otherCatechin derivatives
dc.titleInteraction of Pseudobombax marginatum robyns stem bark extract on the cell surface of Bacillus cereus and Staphylococcus aureus
dc.typeArtigo de periódico
local.citation.epage1069
local.citation.issue2
local.citation.spage1063
local.citation.volume5
local.description.resumoThe search for new drugs has favored the research on medicinal plants as a source of bioactive substances, mainly due to the increased microbial resistance. The aim of this study was to investigate the antibacterial activity of Pseudobombax marginatum against bacteria of clinical interest and its possible mechanism of action. The antibacterial activity of hydroalcoholic extract of Pseudobombax marginatum bark (HAEPMB) and of Butanolic Fraction (BF) was determined by Agar diffusion and dilution methods in which Bacillus cereus was more susceptible, followed by Staphylococcus aureus 29213 and 33591, with minimal inhibitory concentrations (MICs) corresponding to 0.5mg/mL and 1.0mg/mL, respectively. Changes in the bacterial cell ultra structure were shown through SDS-PAGE electrophoresis and Transmission Electron Microscopy, suggesting that P. marginatum interferes in cell surface of B. cereus as its possible mechanism of action. HAEPMB and BF affected the bacterial cell wall with changes in the cytoplasmic membrane and content, causing growth inhibition or cell death. The chemical analysis showed presence of phenolic compounds, among them catechin derivatives, and the activities are attributed to these derivatives.
local.identifier.orcidhttps://orcid.org/0000-0001-8296-6682
local.identifier.orcidhttps://orcid.org/0000-0003-4912-8016
local.identifier.orcidhttps://orcid.org/0000-0001-8238-3380
local.identifier.orcidhttps://orcid.org/0000-0002-9073-1995
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://austinpublishinggroup.com/bacteriology/fulltext/bacteriology-v5-id1063.php

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