Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver

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dc.creatorRoberta Cristelli Fonseca
dc.creatorGabriel Shimizu Bassi
dc.creatorCamila Carvalho Brito
dc.creatorLorena Barreto Rosa
dc.creatorBruna Araújo David
dc.creatorAlan Moreira Araújo
dc.creatorNatália Nóbrega
dc.creatorAriane Barros Diniz
dc.creatorItamar Couto Guedes Jesus
dc.creatorLucíola Silva Barcelos
dc.creatorMarco Antônio Peliky Fontes
dc.creatorDaniella Bonaventura
dc.creatorAlexandre Kanashiro
dc.creatorThiago Mattar Cunha
dc.creatorSílvia Guatimosim
dc.creatorValbert Nascimento Cardoso
dc.creatorSimone Odília Antunes Fernandes
dc.creatorGustavo Batista Menezes
dc.creatorGuillaume de Lartigue
dc.creatorAndré Gustavo Oliveira
dc.date.accessioned2022-04-06T21:26:56Z
dc.date.accessioned2025-09-09T00:53:58Z
dc.date.available2022-04-06T21:26:56Z
dc.date.issued2019-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.bbi.2019.06.041
dc.identifier.issn0889-1591
dc.identifier.urihttps://hdl.handle.net/1843/40843
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrain, Behavior, and Immunity
dc.rightsAcesso Aberto
dc.subjectFígado
dc.subjectNervo vago
dc.subject.otherVagus nerve
dc.subject.otherCholinergic signaling
dc.subject.otherLiver
dc.subject.otherKupffer cells
dc.subject.otherPhagocytosis
dc.titleVagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
dc.typeArtigo de periódico
local.citation.epage454
local.citation.spage444
local.citation.volume81
local.description.resumoThe gastrointestinal (GI) tract harbors commensal microorganisms as well as invasive bacteria, toxins and other pathogens and, therefore, plays a pivotal barrier and immunological role against pathogenic agents. The vagus nerve is an important regulator of the GI tract-associated immune system, having profound effects on inflammatory responses. Among GI tract organs, the liver is a key site of immune surveillance, as it has a large population of resident macrophages and receives the blood drained from the guts through the hepatic portal circulation. Although it is widely accepted that the hepatic tissue is a major target for vagus nerve fibers, the role of this neural circuit in liver immune functions is still poorly understood. Herein we used in vivo imaging techniques, including confocal microscopy and scintigraphy, to show that vagus nerve stimulation increases the phagocytosis activity by resident macrophages in the liver, even on the absence of an immune challenge. The activation of this neural circuit in a non-lethal model of sepsis optimized the removal of bacteria in the liver and resulted in the production of anti-inflammatory and pro-regenerative cytokines. Our findings provide new insights into the neural regulation of the immune system in the liver.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S088915911831225X?via%3Dihub

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