Dental germ tumor: an unusual, cystic, mixed epithelial-mesenchymal odontogenic tumor

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dc.creatorFabricio Passador-Santos
dc.creatorStephanie Joana Martelli
dc.creatorPamela Gomes
dc.creatorLucas Novaes Teixeira
dc.creatorAndresa Borges Soares
dc.creatorRicardo Santiago Gomez
dc.creatorVera Cavalcanti de Araújo
dc.date.accessioned2024-11-28T21:23:14Z
dc.date.accessioned2025-09-08T23:28:04Z
dc.date.available2024-11-28T21:23:14Z
dc.date.issued2020-02-05
dc.identifier.doihttps://doi.org/10.1007/s12105-020-01136-0
dc.identifier.issn1936-0568
dc.identifier.urihttps://hdl.handle.net/1843/78359
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHead and Neck Pathology
dc.rightsAcesso Restrito
dc.subjectOdontoma
dc.subjectOdontogenic tumors
dc.subjectMesenchymal stem cells
dc.subjectClinical study
dc.subjectMicroscopy
dc.subjectBiopsy
dc.subjectDiagnosis, oral
dc.subjectHypesthesia
dc.subjectPain
dc.subjectPalpation
dc.subjectMolar
dc.subjectMandible
dc.subject.otherAmeloblastic fibro odontoma
dc.subject.otherOdontogenic tumors
dc.subject.otherArchegonous odontogenic cyst
dc.subject.otherOdontoma
dc.subject.otherPrimordial odontogenic tumor
dc.titleDental germ tumor: an unusual, cystic, mixed epithelial-mesenchymal odontogenic tumor
dc.typeArtigo de periódico
local.citation.epage1153
local.citation.issue4
local.citation.spage1149
local.citation.volume14
local.description.resumoAlthough odontogenic lesions have been extensively described and studied, anomalous, challenging cases occasionally come to the attention of the pathologist. Here, we report the clinical and microscopic characteristics of an unusual cystic lesion of odontogenic origin. A 16-year-old male presented with swelling and pain to palpation of the right mandible as well as numbness of the right lower lip. Radiographically, the corresponding lesion was well-defined and radiolucent with internal radiopaque foci. It extended from the right first premolar posteriorly, approaching the angle of the mandible, and involved the mandibular first molar which was impacted and displaced. The second and third right mandibular molars were also impacted and displaced. The patient was treated by excisional biopsy under general anesthesia. The histopathologic examination revealed the presence of multicystic areas lined by a thin, non-keratinizing squamous epithelium that resembled the epithelial lining of a dentigerous cyst. In continuity with the cystic lining, areas of myxoid tissue reminiscent of dental papilla were observed. The myxoid tissue formed structures that were surfaced by an epithelium comprising a basal layer of ameloblast-like cells with reverse polarity of the nuclei. Above the basilar cells, additional layers of epithelial cells composed a structure resembling the enamel organ. Subjacent to the basilar ameloblast-like cells, a condensation of mesenchymal cells with polarized nuclei opposite to the ameloblast-like cells was present. These mesenchymal cells resembled odontoblasts. In addition, numerous mineralized structures amongst the odontogenic epithelial tissue were present. To date, the patient remains well and without evidence of recurrence after 36 months of follow-up.
local.identifier.orcidhttps://orcid.org/0000-0003-2777-8640
local.identifier.orcidhttps://orcid.org/0000-0002-7545-5056
local.identifier.orcidhttps://orcid.org/0000-0001-6112-3096
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0003-4087-889X
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12105-020-01136-0

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