Prognostic importance of the lymphovascular invasion in head and neck adenoid cystic carcinoma: a systematic review and meta-analysis

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dc.creatorBárbara Martins de Andrade
dc.creatorSara Ferreira dos Santos Costa
dc.creatorMaria Sissa Pereira Sant'ana
dc.creatorAlbina Altemani
dc.creatorPablo Agustin Vargas
dc.creatorEduardo Rodrigues Fregnani
dc.creatorLucas Guimarães Abreu
dc.creatorAline Carvalho Batista
dc.creatorFelipe Paiva Fonseca
dc.date.accessioned2023-10-20T20:20:29Z
dc.date.accessioned2025-09-09T01:04:36Z
dc.date.available2023-10-20T20:20:29Z
dc.date.issued2019-06
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2019.04.014
dc.identifier.issn13688375
dc.identifier.urihttps://hdl.handle.net/1843/59824
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Oncology
dc.rightsAcesso Aberto
dc.subjectCarcinoma, adenoid cystic
dc.subjectHead and neck neoplasms
dc.subjectPrognosis
dc.subjectAdenoma, pleomorphic
dc.subjectPrevalence
dc.subjectCross-sectional studies
dc.subjectDeath
dc.subjectSurvival
dc.subjectLymphatic metastasis
dc.titlePrognostic importance of the lymphovascular invasion in head and neck adenoid cystic carcinoma: a systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.epage58
local.citation.spage52
local.citation.volume93
local.description.resumoThe presence of lymphovascular invasion is considered a prognostic determinant for different human neoplasms and is frequently taken into account by surgeons and oncologists to determine patients' treatment. However, the exact frequency of this microscopic event and its prognostic impact for patients affected by adenoid cystic carcinoma (AdCC) remains unclear. Therefore, the aim of this study was to carry out a systematic review and meta-analysis to address the prevalence and the prognostic potential of lymphovascular invasion in head and neck AdCC. A literature search on PubMed, Scopus, ClinicalTrials.gov, Web of Science and ProQuest databases was undertaken in January 2019. The primary outcomes of interest were overall survival (OS) and disease-free survival (DFS). The relative frequency of lymphovascular invasion and its possible association with other clinicopathological parameters were addressed. A total of 22 studies and 2117 patients were included in this study. The frequency of lymphovascular invasion ranged from 5.2% to 72.5%. Lymphovascular invasion was associated with an increased likelihood of lymph node metastasis (OR = 2.58; 95% CI 1.61-4.12; p = 0.0001) and death (OR = 3.09; 95% CI 1.82-5.26; p = 0.0001), solid/higher-grade AdCC were more likely to present lymphovascular invasion (OR = 5.51; 95% CI 1.87-16-21; p = 0.002) and patients with this microscopic finding had a significantly lower OS (HR = 8.30; 95% CI 1.68-40.91; p = 0.009) and DFS (HR = 3.76; 95% CI 1.13-12.53; p = 0.03). In conclusion, lymphovascular invasion seems to be a significant predictor of poor prognosis for head and neck AdCC patients.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1368837519301253?via%3Dihub

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