Decreased reemerging auditory brainstem responses under ipsilateral broadband masking as a marker of noise-induced cochlear synaptopathy

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dc.creatorLudimila Labanca
dc.creatorFabrice Giraudet
dc.creatorMarion Souchal
dc.creatorPaul Avan
dc.date.accessioned2023-08-09T21:17:20Z
dc.date.accessioned2025-09-09T01:09:14Z
dc.date.available2023-08-09T21:17:20Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doi10.1097/AUD.0000000000001009
dc.identifier.issn0196-0202
dc.identifier.urihttps://hdl.handle.net/1843/57668
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEar and Hearing
dc.rightsAcesso Restrito
dc.subjectPotenciais Evocados Auditivos
dc.subject.otherAuditory-evoked responses
dc.subject.otherNoise-induced cochlear synaptopathy
dc.titleDecreased reemerging auditory brainstem responses under ipsilateral broadband masking as a marker of noise-induced cochlear synaptopathy
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage1
local.citation.volumePublish Ahead of Print
local.description.resumoObjectives: In mammals, a 2-hr exposure to an octave-band noise (OBN) at 100 to 108 dB SPL induces loss of synaptic ribbons between inner hair cells and auditory nerve fibers with high thresholds of response (hiT neurons), that encode high-intensity sounds. Here, we tackle the challenge of diagnosing this synaptopathy by a noninvasive functional audiological test, ultimately in humans, despite the expected absence of auditory-threshold elevation and of clear electrophysiological abnormal ity, hiT neuron contributions being hidden by those of more sensitive and robust neurons.Design: The noise-induced synaptopathy was replicated in mice (at 94, 97, and 100 dB SPL; n = 7, 7, and 8, respectively, against 8 unexposed controls), without long-lasting auditory-threshold elevation despite a two fold decrease in ribbon-synapse number for the 100-dB OBN exposure. Auditory brainstem responses (ABRs) were collected using a simultaneous broadband noise masker just able to erase the ABR response to a 60-dB tone burst. Tone burst intensity was then increased up to 100 dB SPL for eliciting reemerging ABRs (R-ABRs), dependent on hiT neurons as more sensitive neurons are masked.Results: In most ears exposed to 97-dB-SPL and all ears exposed to 100-dB-SPL OBN, contrary to controls, R-ABRs from the overexposed region have vanished, whereas standard ABR distributions widely overlap.Conclusions: R-ABRs afford an individual noninvasive marker of normal-auditory-threshold cochlear synaptopathy. A simple modification of standard ABRs would allow hidden auditory synaptopathy to be searched in a patient.
local.identifier.orcidhttps://orcid.org/0000-0003-3296-4800
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE FONOAUDIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://europepmc.org/article/med/33625059

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