Clinical and microbiological effects of non-surgical periodontal treatment in individuals with rheumatoid arthritis: a controlled clinical trial

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dc.creatorMarcela de Faria Moura
dc.creatorLuis Otávio de Miranda Cota
dc.creatorTarcília Aparecida da Silva
dc.creatorSheila Cavalca Cortelli
dc.creatorGilda Aparecida Ferreira
dc.creatorMarina Moreira Lopez
dc.creatorFernando de Oliveira Costa
dc.date.accessioned2025-08-28T20:37:57Z
dc.date.accessioned2025-09-09T00:50:27Z
dc.date.available2025-08-28T20:37:57Z
dc.date.issued2021-04
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s10266-020-00566-0
dc.identifier.issn1618-1255
dc.identifier.urihttps://hdl.handle.net/1843/84699
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOdontology
dc.rightsAcesso Restrito
dc.subjectBacteria
dc.subjectClinical trial
dc.subjectPeriodontal debridement
dc.subjectPeriodontitis
dc.subjectArthritis, rheumatoid
dc.subject.otherBacteria
dc.subject.otherClinical trials
dc.subject.otherNonsurgical periodontal debridements
dc.subject.otherPeriodontitis
dc.subject.otherRheumatoid arthritis
dc.titleClinical and microbiological effects of non-surgical periodontal treatment in individuals with rheumatoid arthritis: a controlled clinical trial
dc.typeArtigo de periódico
local.citation.epage493
local.citation.issue2
local.citation.spage484
local.citation.volume109
local.description.resumoThe effect of periodontal treatment on clinical, microbiological and serological parameters of patients with rheumatoid arthritis (RA) are scarce and controversial. The aim of this study was to investigate the influence of non-surgical periodontal treatment on clinical periodontal status, subgingival bacterial levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola and RA activity through a controlled clinical trial on individuals with RA and periodontitis (PE). From a convenience sample, 107 individuals were considered eligible and consecutively allocated in four groups: (1) individuals without PE and RA (- PE-RA, n = 30); (2) individuals without PE and with RA (- PE + RA, n = 23); (3) individuals with PE and RA (+ PE + RA, n = 24); and (4) individuals with PE and without RA (+ PE-RA, n = 30). Full-mouth periodontal clinical examinations, microbiological analysis and Disease Activity Score (DAS-28) evaluations were performed at baseline (T1) and 45 days after non-surgical periodontal treatment (T2). At T1, individuals + PE + RA showed greater severity of PE than + PE-RA individuals. At T2, significant reductions were observed in all periodontal clinical parameters in both groups (p < 0.001) with a significant reduction in DAS-28 in + PE + RA (p = 0.011). Individuals + PE-RA and + PE-RA showed significant reductions for all bacteria (p < 0.001). Additionally, P. gingivalis demonstrated an expressively significant reduction in + PE + RA (p < 0.001). Non-surgical periodontal treatment was effective on improving the clinical periodontal condition, improving the RA clinical status and reducing the presence of periodontal pathogens. Brazilian Registry of Clinical Trials (ReBEC) protocol #RBR-8g2bc8 ( https://www.ensaiosclinicos.gov.br/rg/RBR-8g2bc8/ ).
local.identifier.orcidhttps://orcid.org/0000-0003-1517-5842
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0003-0809-6935
local.identifier.orcidhttps://orcid.org/0000-0002-1352-7261
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10266-020-00566-0

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