Periodontitis and type 2 diabetes among women with previous gestational diabetes: epidemiological and immunological aspects in a follow-up of three years

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dc.creatorRafael Paschoal esteves Lima acesso aberto
dc.creatorLuis Otávio de Miranda Cota
dc.creatorTarcília Aparecida da Silva
dc.creatorSheila Cavalca Cortelli
dc.creatorJosé Roberto Cortelli
dc.creatorFernando de Oliveira Costa
dc.date.accessioned2025-04-01T16:05:29Z
dc.date.accessioned2025-09-08T23:07:38Z
dc.date.available2025-04-01T16:05:29Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1678-77572016-0367
dc.identifier.issn1678-7765
dc.identifier.urihttps://hdl.handle.net/1843/81174
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Applied Oral Science
dc.rightsAcesso Aberto
dc.subjectDiabetes mellitus
dc.subjectDiabetes, gestational
dc.subjectDiabetes mellitus, type 2
dc.subjectPeriodontitis
dc.subjectPregnant people
dc.subjectC-reactive protein
dc.subject.otherGestational diabetes
dc.subject.otherDiabetes mellitus
dc.subject.otherDiabetes mellitus, type 2
dc.subject.otherPeriodontitis
dc.subject.otherPregnant women
dc.titlePeriodontitis and type 2 diabetes among women with previous gestational diabetes: epidemiological and immunological aspects in a follow-up of three years
dc.typeArtigo de periódico
local.citation.epage139
local.citation.issue2
local.citation.spage130
local.citation.volume25
local.description.resumoPeriodontitis can contribute to the development of insulin resistance. Gestational diabetes is a risk factor for type 2 diabetes. Therefore, periodontitis, when associated with gestational diabetes, could increase the risk for the development of type 2 diabetes after pregnancy. Objective The aim of this study was to verify the incidence on the development of type 2 diabetes in women with previous gestational diabetes with and without periodontitis after a three-year time interval. Material and Methods Initial sample of this follow-up study consisted of 90 women diagnosed with gestational diabetes who underwent periodontal examination. After three years, 49 women were subjected to new periodontal examination and biological, behavioral, and social data of interest were collected. Additionally, the quantification of the C-reactive protein in blood samples was performed. Fasting glucose and glycated hemoglobin levels were requested. Saliva samples were collected for quantification of interleukin 6 and 10, tumor necrosis factor α, matrix metalloproteinase 2 and 9. Results The incidence of type 2 diabetes mellitus was 18.4% and of periodontitis was 10.2%. There was no significant difference in the incidence of type 2 diabetes mellitus among women with and without periodontitis. It was observed impact of C-reactive protein in the development of type 2 diabetes mellitus. However, it was not observed impact of periodontitis on the development of type 2 diabetes mellitus among women with previous gestational diabetes. Conclusions It was not observed impact of periodontitis on the development of type 2 diabetes among women with previous gestational diabetes. The impact of C-reactive protein in the development of type 2 diabetes mellitus highlights the importance of an inflammatory process in the diabetes pathogenesis.
local.identifier.orcidhttps://orcid.org/0000-0003-4343-3845
local.identifier.orcidhttps://orcid.org/0000-0003-1517-5842
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0003-0809-6935
local.identifier.orcidhttps://orcid.org/0000-0001-5147-0705
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/jaos/a/nYRYKYwcZQP3rV9ygjKDQFB/?lang=en

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