Sub-additive effects of photodynamic therapy combined with erlotinib for the treatment of epidermoid carcinoma: an in vitro study

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dc.creatorSávio Morato Lacerda Gontijo
dc.creatorRenata Cunha Felizali
dc.creatorPedro Pires Goulart Guimarães
dc.creatorRobson Augusto Souza dos Santos
dc.creatorRubén Dario Sinisterra Millán
dc.creatorMaría Esperanza Cortés Segura
dc.creatorPatrícia Valente Araújo
dc.date.accessioned2023-12-13T14:26:48Z
dc.date.accessioned2025-09-08T23:54:00Z
dc.date.available2023-12-13T14:26:48Z
dc.date.issued2017-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.identifier.doihttps://doi.org/10.1016/j.pdpdt.2017.03.010
dc.identifier.issn1873-1597
dc.identifier.urihttps://hdl.handle.net/1843/61975
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.rightsAcesso Restrito
dc.subjectFotoquimioterapia
dc.subjectCarcinoma de células escamosas
dc.subjectCâncer - Tratamento
dc.subjectAgentes antineoplásicos
dc.subject.otherPhotodynamic therapy
dc.subject.otherMethylene blue
dc.subject.otherErlotinib
dc.subject.otherA431 epidermoid carcinoma
dc.titleSub-additive effects of photodynamic therapy combined with erlotinib for the treatment of epidermoid carcinoma: an in vitro study
dc.typeArtigo de periódico
local.citation.epage256
local.citation.spage252
local.citation.volume18
local.description.resumoBackground: Photodynamic therapy (PDT) is an antitumour treatment that employs the combination of a photosensitive compound, oxygen and visible light. To improve the antitumour activity of PDT, the present study used the strategy of combining PDT with erlotinib (ERL), a drug frequently used in the treatment of epidermoid carcinoma. Methods: An MTT cell viability assay was used to evaluate the cytotoxicity of PDT combined with ERL on A431 epidermoid carcinoma cells in vitro. This study evaluated the cytotoxicity of the following treatments: red laser irradiation (660 nm) at different power densities (1.25–180 J/cm2), the photosensitizer methylene blue (MB) at concentrations of 0.39–100 μM, PDT (12.5 μM MB and laser power densities from 1.25 to 180 J/cm2), and PDT (12.5 μM MB and a laser density of 120 J/cm2) plus ERL (1 μM). Results: The laser power densities that were tested showed no cytotoxicity in A431 cells. MB showed a dose-dependent cytotoxicity. In PDT, an increase in the dose of light resulted in an increase in the cytotoxicity of MB. In addition, there was a sub-additive effect between PDT and ERL compared to the effect of each therapy alone. Conclusions: The sub-additive effect between PDT and ERL suggests that their combination may be an important strategy in the treatment of epidermoid carcinoma.
local.identifier.orcidhttps://orcid.org/0000-0002-7803-4345
local.identifier.orcidhttps://orcid.org/0000-0003-4534-2779
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0002-0560-8491
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1572100016302186

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