The potential use of simvastatin for cancer treatment: a review

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dc.creatorJaqueline Aparecida Duarte
dc.creatorAndré Luís Branco de Barros
dc.creatorElaine Amaral Leite
dc.date.accessioned2023-07-17T20:27:24Z
dc.date.accessioned2025-09-09T00:59:21Z
dc.date.available2023-07-17T20:27:24Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2021.111858
dc.identifier.issn1950-6007
dc.identifier.urihttps://hdl.handle.net/1843/56501
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.rightsAcesso Aberto
dc.subjectCancer - Tratamento
dc.subjectEstatinas (Agentes cardiovasculares)
dc.subject.otherSimvastatin
dc.subject.otherCancer treatment
dc.subject.otherCo-administration
dc.subject.otherStatins
dc.titleThe potential use of simvastatin for cancer treatment: a review
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume141
local.description.resumoStatins, typically used to reduce lipid levels, have been rediscovered for exhibiting anticancer activities. Among them, especially simvastatin may influence the proliferation, migration, and survival of cancer cells. The concept of using statins to treat cancer has been adopted since the 1990s In vitro and in vivo experiments and cohort studies using statins have been carried out to demonstrate their antitumor effects (such as proliferation and migration impairment) by influencing inflammatory and oxidative stress-related tumorigenesis. Nevertheless, the biological mechanisms for these actions are not fully elucidated. In this review, we present an overview of the most important studies conducted from 2015 to date on the use of simvastatin in cancer therapy. This review brings the most recent perspectives and targets in epidemiological, in vitro, and in vivo studies, regarding the use of simvastatin alone or in combination with other drugs for the treatment of various types of cancer.
local.identifier.orcidhttps://orcid.org/0000-0001-6841-3061
local.identifier.orcidhttps://orcid.org/0000-0001-7979-1156
local.identifier.orcidhttps://orcid.org/0000-0001-8812-3811
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332221006405

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