Epidemiological surveillance reveals the rise and establishment of the omicron SARS-CoV-2 variant in Brazil

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dc.creatorJoice do Prado Silva
dc.creatorLuíza Campos Guerra de Araújo e Santos
dc.creatorAlessandro Clayton de Souza Ferreira
dc.creatorRenan Pedra de Souza
dc.creatorRenato Santana de Aguiar
dc.creatorDanielle Alves Gomes Zauli
dc.creatorAline Brito de Lima
dc.creatorLuige Biciati Alvim
dc.creatorFrederico Scott Varella Malta
dc.creatorCristiane Pinheiro Toscano Brito Mendonça
dc.creatorAndré Henrique Barbosa de Carvalho
dc.creatorJéssica Silqueira Hickson Rios
dc.creatorPaula Luize Camargos Fonseca
dc.creatorDaniel Costa Queiroz
dc.date.accessioned2025-01-23T20:54:45Z
dc.date.accessioned2025-09-08T23:11:04Z
dc.date.available2025-01-23T20:54:45Z
dc.date.issued2023-04-20
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/v15041017
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/1843/79442
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofViruses
dc.rightsAcesso Aberto
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectEpidemiologia
dc.subjectEpidemias
dc.subjectPandemias
dc.subject.otherSARS-CoV-2
dc.subject.otherVariants
dc.subject.otherEpidemiologic surveillance
dc.subject.otherCOVID-19
dc.subject.otherViral load
dc.subject.otherSymptoms
dc.titleEpidemiological surveillance reveals the rise and establishment of the omicron SARS-CoV-2 variant in Brazil
dc.typeArtigo de periódico
local.citation.epage15
local.citation.issue4
local.citation.spage1
local.citation.volume15
local.description.resumoThe introduction of SARS-CoV-2 variants of concern (VOCs) in Brazil has been associated with major impacts on the epidemiological and public health scenario. In this study, 291,571 samples were investigated for SARS-CoV-2 variants from August 2021 to March 2022 (the highest peak of positive cases) in four geographical regions of Brazil. To identify the frequency, introduction, and dispersion of SARS-CoV-2 variants in 12 Brazilian capitals, VOCs defining spike mutations were identified in 35,735 samples through genotyping and viral genome sequencing. Omicron VOC was detected in late November 2021 and replaced the Delta VOC in approximately 3.5 weeks. We estimated viral load differences between SARS-CoV-2 Delta and Omicron through the evaluation of the RT-qPCR cycle threshold (Ct) score in 77,262 samples. The analysis demonstrated that the Omicron VOC has a lower viral load in infected patients than the Delta VOC. Analyses of clinical outcomes in 17,586 patients across the country indicated that individuals infected with Omicron were less likely to need ventilatory support. The results of our study reinforce the importance of surveillance programs at the national level and showed the introduction and faster dispersion of Omicron over Delta VOC in Brazil without increasing the numbers of severe cases of COVID-19.
local.identifier.orcidhttps://orcid.org/0000-0001-9553-4328
local.identifier.orcidhttps://orcid.org/0000-0001-5180-3717
local.identifier.orcidhttps://orcid.org/0000-0002-6607-8818
local.identifier.orcidhttps://orcid.org/0000-0001-6192-3587
local.identifier.orcidhttps://orcid.org/0000-0003-3432-8146
local.identifier.orcidhttps://orcid.org/0000-0001-9495-0987
local.identifier.orcidhttps://orcid.org/0000-0002-7031-2902
local.identifier.orcidhttps://orcid.org/0000-0002-8103-9235
local.identifier.orcidhttps://orcid.org/0000-0002-9479-4432
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/1999-4915/15/4/1017

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