Decreased percentage of cd4+ lymphocytes expressing chemokine receptors in bipolar disorder

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dc.creatorIzabela Guimarães Barbosa
dc.creatorAntonio l. Teixeira
dc.creatorNatalia p. Rocha
dc.creatorErica l. Vieira
dc.creatorMehmet a. Camkurt
dc.creatorRodrigo b. Huguet
dc.creatorFabio t. l. Guimarães
dc.creatorGustavo e. de Brito-melo
dc.creatorVanessa a. Mendonça
dc.creatorMoises e. Bauer
dc.date.accessioned2023-07-17T21:54:01Z
dc.date.accessioned2025-09-09T00:19:12Z
dc.date.available2023-07-17T21:54:01Z
dc.date.issued2019-03-14
dc.identifier.issn09242708
dc.identifier.urihttps://hdl.handle.net/1843/56549
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Neuropsychiatrica
dc.rightsAcesso Restrito
dc.subjectTranstorno bipolar
dc.subjectReceptores de Quimiocinas
dc.subjectPsiconeuroimunologia
dc.subject.otherBipolar disorder
dc.subject.otherReceptors, Chemokine
dc.subject.otherPsychoneuroimmunology
dc.titleDecreased percentage of cd4+ lymphocytes expressing chemokine receptors in bipolar disorder
dc.typeArtigo de periódico
local.citation.epage16
local.citation.spage1
local.citation.volume14
local.description.resumoObjective:Although accumulating evidence supports the hypothesis that immune/inflammatory mechanisms are associated with the pathophysiology of bipolar disorder (BD), data about the profile of chemokines (chemotactic cytokines) and chemokine receptors are still scarce. The current study was designed to evaluate the expression of chemokine receptors on lymphocytes of patients with BD in comparison with controls.Methods:Thirty-three patients with type I BD (N = 21 in euthymia; N = 6 in mania/hypomania; N = 6 in depression) and 22 age- and sex-matched controls were subjected to clinical evaluation and peripheral blood draw. The expression of chemokine receptors CCR3, CCR5, CXCR4, and CXCR3 on CD4+ and CD8+ lymphocytes was assessed by flow cytometry.Results: Patients with BD had decreased percentage of CD4+CXCR3+ (p = 0.024), CD4+CCR3+ (p = 0.042), and CD4+CCR5+ (0.013) lymphocytes in comparison with controls. The percentage of both CD4+ and CD8+ lymphocytes expressing the chemokine receptor CXCR4 was similar in patients with BD and controls. Likewise, the percentages of CD8+CXCR3+, CD8+CCR3+, and CD8+CCR5+ lymphocytes were similar in patients with BD and controls.Conclusion:Our findings reinforce the hypothesis that immune pathways, especially involving CD4+ lymphocytes, are involved in the physiopathology of BD.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.cambridge.org/core/journals/acta-neuropsychiatrica/article/abs/decreased-percentage-of-cd4-lymphocytes-expressing-chemokine-receptors-in-bipolar-disorder/08681909CC64CC29567F9C4BC5456600

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