Ameloblastic carcinoma: a brazilian collaborative study of 17 cases

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dc.creatorAdriano Mota Loyola
dc.creatorSuzana Orsini Machado Catanhede Souza
dc.creatorJean Nunes de Souza
dc.creatorSergio Vitorino Cardoso
dc.creatorPaulo Rogério de Faria
dc.creatorJoão Paulo Silva Servato
dc.creatorAna Lúcia Amaral Eisenberg
dc.creatorFernando Luiz Dias
dc.creatorMaria Theresa de Souza Accioly
dc.creatorCarolina Cavalieri Gomes
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-06-05T20:33:12Z
dc.date.accessioned2025-09-09T01:11:27Z
dc.date.available2025-06-05T20:33:12Z
dc.date.issued2016-10
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/his.12995
dc.identifier.issn1365-2559
dc.identifier.urihttps://hdl.handle.net/1843/82836
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHistopathology (Oxford)
dc.rightsAcesso Restrito
dc.subjectAmeloblastoma
dc.subjectCarcinoma
dc.subjectEpidemiology
dc.subjectOdontogenic Tumors
dc.subjectPathology
dc.subjectKeratins
dc.subjectKi-67 antigen
dc.subjectCell count
dc.subjectProteins
dc.subjectImmunohistochemistry
dc.subjectHistology
dc.subjectPrognosis
dc.subjectTherapeutics
dc.subjectMandible
dc.subjectRecurrence
dc.subjectNeoplasm metastasis
dc.subjectDiagnosis
dc.subject.otherAmeloblastoma
dc.subject.otherCarcinoma
dc.subject.otherEpidemiology
dc.subject.otherOdontogenic tumors
dc.subject.otherPathology
dc.titleAmeloblastic carcinoma: a brazilian collaborative study of 17 cases
dc.typeArtigo de periódico
local.citation.epage701
local.citation.issue4
local.citation.spage687
local.citation.volume69
local.description.resumoAims: Ameloblastic carcinoma (AMECA) is an odontogenic malignancy that combines the histological features of ameloblastoma and cytological atypia. Because of its rarity, it poses difficulties in diagnosis. The aim of this study was to investigate the socio-demographic data, histopathology, immunohistochemical features, treatment and outcomes of 17 cases. Methods and results: Descriptive statistical analyses were used to portray the clinicopathological data collected, retrospectively. Log-rank tests were performed to determine new prognostic factors. Lesions were immunostained for Ki67, p16, p53, and cytokeratins (CKs), and compared with solid/multicystic ameloblastomas (n = 15). AMECA was mostly diagnosed at a late stage, affecting the posterior mandible of male patients in their fifth decade of life. Recurrence was diagnosed in nearly 90% of treated patients, and metastasis occurred in four patients. The mean number of Ki67-positive cells was 86.4 ± 66 per field. Tumours were focally positive for CK7, CK8, CK14, and CK18, and diffusely positive for CK19, p53, and p16. AMECA showed increased immunoexpression of CK18, CK19, p16, p53 and Ki67 as compared with benign cases. Conclusions: Our study has contributed to the improved characterization of the epidemiology, prognostic markers, treatment options and outcomes of AMECA. Current criteria must be reviewed to simplify the diagnostic process for these neoplasms.
local.identifier.orcidhttps://orcid.org/0000-0001-9707-9365
local.identifier.orcidhttps://orcid.org/0000-0003-1809-0617
local.identifier.orcidhttps://orcid.org/0000-0003-2650-3960
local.identifier.orcidhttps://orcid.org/0000-0003-1783-8777
local.identifier.orcidhttps://orcid.org/0000-0002-0170-1170
local.identifier.orcidhttps://orcid.org/0000-0003-1000-7436
local.identifier.orcidhttps://orcid.org/0000-0002-1423-0398
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/his.12995

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