Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro

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dc.creatorAlice Gameiro Leonel
dc.creatorHerman Sander Mansur
dc.creatorAlexandra Ancelmo Piscitelli Mansur
dc.creatorAnderson Caires de Jesus
dc.creatorSandhra Maria de Carvalho
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.creatorLuis Eugenio Fernandez Outon
dc.creatorJosé Domingos Ardisson
dc.date.accessioned2022-11-16T13:16:50Z
dc.date.accessioned2025-09-08T23:04:13Z
dc.date.available2022-11-16T13:16:50Z
dc.date.issued2019
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetos
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.ijbiomac.2019.04.006
dc.identifier.issn01418130
dc.identifier.urihttps://hdl.handle.net/1843/47231
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.rightsAcesso Aberto
dc.subjectPolissacarídeos
dc.subjectNanotecnologia
dc.subjectNanopartículas magnéticas
dc.subjectNanocompósitos
dc.subject.otherPolysaccharide
dc.subject.otherCarboxymethyl cellulose
dc.subject.otherGreen nanotechnology
dc.subject.otherMagnetic nanoparticle
dc.subject.otherNanocomposite
dc.titleSynthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro
dc.typeArtigo de periódico
local.citation.epage691
local.citation.spage677
local.citation.volume132
local.description.resumoNovel core-shell superparamagnetic nanofluids composed of magnetic iron oxide (Fe3O4, MION) and cobalt-doped (CoxFe3-xO4, Co-MION) nanoparticles functionalized with carboxymethyl cellulose (CMC) ligands were designed and produced via green colloidal aqueous process. The effect of the degree of substitution (DS = 0.7 and 1.2) and molecular mass (Mw) of CMC and cobalt doping concentration on the physicochemical and magnetic properties of these nanoconjugates were comprehensively investigated using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, transmission electron microscopy (TEM) with selected area electron diffraction, X-ray fluorescence, dynamic light scattering (DLS), zeta potential (ZP) analysis, vibrating sample magnetometry (VSM) and electron paramagnetic resonance spectroscopy (EPR). The results demonstrated the effect of concentration of carboxylate groups and Mw of CMC on the hydrodynamic dimension, zeta potential, and generated heat by magnetic hyperthermia of MION nanoconjugates. Co-doping of MION showed significant alteration of the electrostatic balance of charges of the nanoconjugates interpreted as effect of surface interactions. Moreover, the VSM and EPR results proved the superparamagnetic properties of these nanocolloids, which were affected by the presence of CMC and Co-doping of iron oxide nanoparticles. These magnetic nanohybrids behaved as nanoheaters for killing brain cancer cells in vitro with prospective future applications in oncology and nanomedicine.
local.identifier.orcidhttps://orcid.org/0000-0002-8798-4182
local.identifier.orcidhttps://orcid.org/0000-0002-3032-495X
local.identifier.orcidhttps://orcid.org/0000-0003-1526-2508
local.identifier.orcidhttps://orcid.org/0000-0003-2273-2993
local.identifier.orcidhttps://orcid.org/0000-0001-6665-8647
local.identifier.orcidhttps://orcid.org/0000-0002-7562-0285
local.identifier.orcidhttps://orcid.org/0000-0003-3264-337X
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0141813019305537

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