Traumatic brain injury biomarkers in pediatric patients: a systematic review

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dc.creatorAntônio Lúcio Teixeira
dc.creatorAna Cristina Simões e Silva
dc.creatorLucas Alexandre Santos Marzano
dc.creatorAline Silva de Miranda
dc.creatorJoao Pedro Thimotheo Batista
dc.creatorMarina de Abreu Arruda
dc.creatorMaíra Glória de Freitas Cardoso
dc.creatorJoão Luís Vieira Monteiro de Barros
dc.creatorJanaína Matos Moreira
dc.creatorPriscila Menezes Ferri Liu
dc.date.accessioned2023-07-31T20:48:28Z
dc.date.accessioned2025-09-08T23:32:09Z
dc.date.available2023-07-31T20:48:28Z
dc.date.issued2022
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s10143-021-01588-0
dc.identifier.issn14372320
dc.identifier.urihttps://hdl.handle.net/1843/57269
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNeurosurgical Review
dc.rightsAcesso Restrito
dc.subjectLesões Encefálicas Traumáticas
dc.subjectPediatria
dc.subjectBiomarcadores Farmacológicos
dc.subjectSubunidade beta da Proteína Ligante de Cálcio S100
dc.subjectNeuroimagem
dc.subject.otherTraumatic brain injury
dc.subject.otherPediatrics
dc.subject.otherBiomarkers
dc.subject.otherS100B
dc.subject.otherNeuroimaging
dc.titleTraumatic brain injury biomarkers in pediatric patients: a systematic review
dc.typeArtigo de periódico
local.citation.epage191
local.citation.issue45
local.citation.spage167
local.description.resumoTraumatic brain injury (TBI) is the main cause of pediatric trauma death and disability worldwide. Recent studies have sought to identify biomarkers of TBI for the purpose of assessing functional outcomes. The aim of this systematic review was to evaluate the utility of TBI biomarkers in the pediatric population by summarizing recent fndings in the medical literature. A total of 303 articles were retrieved from our search. An initial screening to remove duplicate studies yielded 162 articles. After excluding all articles that did not meet the inclusion criteria, 56 studies were gathered. Among the 56 studies, 36 analyzed serum biomarkers; 11, neuroimaging biomarkers; and 9, cerebrospinal fuid (CSF) biomarkers. Most studies assessed biomarkers in the serum, refecting the feasibility of obtaining blood samples compared to obtaining CSF or performing neuroimaging. S100B was the most studied serum biomarker in TBI, followed by SNE and UCH-L1, whereas in CSF analysis, there was no unanimity. Among the diferent neuroimaging techniques employed, difusion tensor imag ing (DTI) was the most common, seemingly holding diagnostic power in the pediatric TBI clinical setting. The number of cross-sectional studies was similar to the number of longitudinal studies. Our data suggest that S100B measurement has high sensitivity and great promise in diagnosing pediatric TBI, ideally when associated with head CT examination and clinical decision protocols. Further large-scale longitudinal studies addressing TBI biomarkers in children are required to establish more accurate diagnostic protocols and prognostic tools.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10143-021-01588-0

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