Toxoplasma gondii infection and chronic schizophrenia: is there any association?

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dc.creatorSalvina Maria Decampos-carli
dc.creatorJoão Vinícius Salgado
dc.creatorAntonio Lucio Teixeira Junior
dc.creatorÉrica Leandro Marciano Vieira
dc.creatorNatalia Pessoa Rocha
dc.creatorKeliane de Oliveira
dc.creatorFernanda Carneiro Guimarães
dc.creatorIzabela Guimarães Barbosa
dc.creatorJoão Luís Vieira Monteiro de Barros
dc.creatorOlaoluwa Okusaga
dc.creatorOlindo Assis Martins-filho
dc.date.accessioned2023-07-14T22:40:19Z
dc.date.accessioned2025-09-09T00:44:16Z
dc.date.available2023-07-14T22:40:19Z
dc.date.issued2017-10-14
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/0101-60830000000140
dc.identifier.issn1806938X
dc.identifier.urihttps://hdl.handle.net/1843/56329
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Clinical Psychiatry (São Paulo)
dc.rightsAcesso Aberto
dc.subjectToxoplasma
dc.subjectEsquizofrenia
dc.subjectTranstornos Cognitivos
dc.subjectDepressão
dc.subjectQualidade de vida
dc.subject.otherToxoplasma gondii
dc.subject.otherSchizophrenia
dc.subject.otherCognition
dc.subject.otherDepression
dc.subject.otherQuality of life
dc.titleToxoplasma gondii infection and chronic schizophrenia: is there any association?
dc.typeArtigo de periódico
local.citation.epage148
local.citation.issue6
local.citation.spage145
local.citation.volume44
local.description.resumoBackground: Toxoplasma gondii (T. gondii) infection has been identified as a risk factor for schizophrenia. Objectives: Herein, we sought to evaluate the association between T. gondii infection and clinical symptoms and quality of life in patients with schizophrenia. Methods: We conducted a cross-sectional study with 48 patients with chronic schizophrenia and 40 controls. Peripheral blood was drawn, and IgM and IgG anti-T. gondii antibodies were evaluated by Enzyme-Linked Immunosorbent Assay (ELISA). Depressive, positive and negative symptoms were assessed, respectively, by the Calgary Depression Scale (CDS) and the Positive and Negative Syndrome Scale (PANSS). Cognitive performance was assessed in patients by the Brazilian version of the Schizophrenia Cognition Rating Scale (SCoRS-BR). Quality of life was assessed by the Brazilian version of the Quality of Life in Schizophrenia scale (QLS-BR). Results: The prevalence and titers of T. gondii IgM and IgG antibodies did not differ between patients and controls. The positive serology for T. gondii IgG antibodies was not associated with illness symptoms, cognitive performance, depressive symptoms or quality of life. Discussion: Our findings suggest that toxoplasmosis infection is not associated with severity of symptoms, quality of life, cognitive or depressive symptoms in schizophrenia patients.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/rpc/a/tLzT6y34hmXn6dwngNXK4tQ/

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