Mandible protraction alters type i collagen, osteocalcin and osteonectin gene expression in adult mice condyle

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dc.creatorPatricia Valerio
dc.creatorFilipi Perfeito
dc.creatorLivia P. Moura
dc.creatorDeborah N. Ribeiro
dc.creatorSimone Odília Antunes Fernandes
dc.creatorAlmir de Sousa Martins
dc.creatorMaria de Fátima Leite
dc.date.accessioned2022-02-23T23:28:59Z
dc.date.accessioned2025-09-09T00:36:26Z
dc.date.available2022-02-23T23:28:59Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doidoi: 10.11138/ads/2017.8.3.095
dc.identifier.issn00034681
dc.identifier.urihttps://hdl.handle.net/1843/39629
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnnali Di Stomatologia
dc.rightsAcesso Aberto
dc.subjectGenética
dc.subject.otherBone biology
dc.subject.otherGrowth evaluation
dc.subject.otherMolecular biology
dc.subject.otherCondyle growth
dc.subject.otherCT
dc.subject.otherGene expression
dc.titleMandible protraction alters type i collagen, osteocalcin and osteonectin gene expression in adult mice condyle
dc.typeArtigo de periódico
local.citation.epage103
local.citation.issue3
local.citation.spage95
local.citation.volume8
local.description.resumoMandible condyle remodeling is a great challenge on craniofacial growth studies. The great majority of the reports deals with growing period. However, there is a great necessity to clarify the importance of functional stimulation on adult mandible condyle remodeling. By using an adult mouse model, we investigated the influence of mandible forwarding on condyle remodeling and gene expression by bone forming cells. Tomographic and scintigraphic evaluations showed sagittal growth and cell activity enhancement. RT-PCR showed that Type I collagen, osteocalcin and osteonectin expression level can be altered. We showed that functional stimulation is necessary to maintain the regular gene expression by condyle bone forming cells in adult mice. It opens new frame for further investigations aiming new clinical approaches to temporomandibular joint problems treatment, as well as mandible retrusion treatment.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897095/

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