The absence of eosinophils is associated with early metastatic lesions in Leishmania amazonensis-infected mice

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dc.creatorGregório Guilherme Almeida
dc.creatorTassiane Assíria Martins Luehring
dc.creatorPierre Henrique de Menezes Paixão
dc.creatorRodrigo Pedro Soares
dc.creatorAndré Luís Branco de Barros
dc.creatorRubens Lima do Monte-Neto
dc.creatorWagner Luiz Tafuri
dc.creatorDeborah Aparecida Negrão-Corrêa
dc.creatorRicardo Gonçalves
dc.date.accessioned2026-03-02T21:00:21Z
dc.date.issued2024-01-08
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1590/0074-02760220242
dc.identifier.issn1678-8060
dc.identifier.urihttps://hdl.handle.net/1843/1847
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz (MIOC)
dc.rightsAcesso aberto
dc.subjectEosinófilos
dc.subjectInfecção
dc.subjectDoença
dc.subjectLeishmania
dc.subjectCamundongos
dc.subject.otherLeishmania
dc.subject.otherEosinophil
dc.subject.otherDisseminated leishmaniasis
dc.titleThe absence of eosinophils is associated with early metastatic lesions in Leishmania amazonensis-infected mice
dc.typeArtigo de periódico
local.citation.epage7
local.citation.spage1
local.citation.volume119
local.creator.Latteshttp://lattes.cnpq.br/5140783997086814
local.creator.Latteshttp://lattes.cnpq.br/1941221181913452
local.creator.Latteshttp://lattes.cnpq.br/3805642883065301
local.creator.Latteshttp://lattes.cnpq.br/5557656124686682
local.creator.Latteshttp://lattes.cnpq.br/7840903429496920
local.creator.Latteshttp://lattes.cnpq.br/2817016666672297
local.creator.Latteshttp://lattes.cnpq.br/5579868951470507
local.creator.Latteshttp://lattes.cnpq.br/3655645192101507
local.creator.Latteshttp://lattes.cnpq.br/5656733095894626
local.description.resumoBACKGROUND Eosinophils are granulocytes that rapidly increase frequency in the bloodstream during helminthic infections and allergic responses. They are found in tissue infected by Leishmania during early disease, but their role during infection is not entirely understood. OBJECTIVES We aim to compare the disease due to Leishmania amazonensis in BALB/c and Δdbl GATA1 mice, which lack eosinophils. METHODS BALB/c and Δdbl-GATA1 mice infected with L. amazonensis were observed for several weeks. The parasite load and dissemination pattern were assessed. FINDINGS The Δdbl-GATA1 mice developed an anticipated dissemination of L. amazonensis and a worsening disease. No differences were found in the lesion development or the parasite load in the footpad among Δdbl-GATA1 mice and BALB/c eight weeks after infection. However, nine weeks after infection, massive growth of metastatic lesions appeared in several parts of the skin in Δdbl-GATA1 mice, weeks earlier than BALB/c. We observed increased parasites in the bloodstream, probably an essential dissemination route. Thirteen weeks after infection, metastatic lesions were found in all Δdbl-GATA1 mice. MAIN CONCLUSION These results suggest a protective role of eosinophils in delaying the disease caused by L. amazonensis, although several limitations of this mice strain must be considered.
local.identifier.orcidhttps://orcid.org/0000-0003-1108-1160
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PARASITOLOGIA
local.publisher.initialsUFMG
local.subject.cnpqCIENCIAS BIOLOGICAS
local.url.externahttps://www.scielo.br/j/mioc/a/cs4qX9kKpr3c89yhh9HnLrk/?format=html&lang=en

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