Increased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus

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dc.creatorMaria Fernanda Gontijo Sepulvedafusaro
dc.creatorJovita Lane Soares Santos Zanini
dc.creatorIvani Novato Silva
dc.date.accessioned2024-06-11T14:47:53Z
dc.date.accessioned2025-09-09T01:07:23Z
dc.date.available2024-06-11T14:47:53Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1186/s13098-016-0190-0
dc.identifier.issn1758-5996
dc.identifier.urihttps://hdl.handle.net/1843/69081
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofDiabetology & Metabolic Syndrome
dc.rightsAcesso Aberto
dc.subjectDiabetes Mellitus
dc.subjectEspessura Intima-Media Carotídea
dc.subjectAterosclerose
dc.subjectUltrassonografia
dc.subject.otherDiabetes Mellitus
dc.subject.otherCarotid intima-media thickness
dc.subject.otherAtherosclerosis, Risk Factors
dc.subject.otherUltrasonography
dc.titleIncreased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue74
local.citation.spage1
local.citation.volume8
local.description.resumoBackground Increased carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is an independent predictor of future cardiovascular events, and has been reported in children with various chronic diseases, including type 1 diabetes mellitus (DM1). Objectives Evaluate CIMT and its association with cardiovascular risk factors in Brazilian adolescents with DM1. Methods Cross-sectional study of 118 adolescents, 57 with DM1 and no chronic complications related to the disease, and 61 healthy individuals. Clinical, biochemical, and high-resolution B-mode ultrasonographic evaluations according to the Consensus Statement of the American Society of Echocardiography CIMT Task Force were performed. Results Adolescents with diabetes (66.6% female) were 14.5 ± 2.9 years old and had 9.0 ± 4.0 years of disease duration. The healthy adolescents (62.3% female) were 14.3 ± 2.6 years old. All the adolescents had blood pressure within their reference ranges. In 66% of DM1 adolescents the systolic blood pressure was >50th percentile. Increased CIMT was observed in adolescents with diabetes compared with those in the control group: 0.53 vs 0.51 mm (p < 0.004) on the right side, and 0.55 vs 0.51 mm (p < 0.001) on the left side. CIMT presented independent and positive associations with diabetes duration, total cholesterol level, low-density lipoprotein cholesterol level, and systolic blood pressure percentile in DM1 adolescents. Conclusions Increased CIMT was observed in young Brazilian adolescents with DM1, and was associated with cardiovascular risk factors. CIMT assessment may be useful for the early identification and monitoring of cardiovascular risk in this age group.
local.identifier.orcidhttps://orcid.org/0000-0002-3585-4917
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEM
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://dmsjournal.biomedcentral.com/articles/10.1186/s13098-016-0190-0#rightslink

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