Effect of 3-UTR RET variants on RET mRNA secondary structure and disease presentation in medullary thyroid carcinoma

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dc.creatorLucieli Ceolin
dc.creatorGerald Weber
dc.creatorAna Luiza Silva Maia
dc.creatorMírian Romitti
dc.creatorDébora Rodrigues Siqueira
dc.creatorCarla Vaz Ferreira Vargas
dc.creatorJessica Oliboni Scapineli
dc.creatorBeatriz Maria de Azevedo Assis Brasil
dc.creatorRodolfo Vieira Maximiano
dc.creatorTauanne Dias Amarante
dc.creatorMíriam Celi de Souza Nunes
dc.date.accessioned2024-03-11T18:47:30Z
dc.date.accessioned2025-09-08T23:10:10Z
dc.date.available2024-03-11T18:47:30Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPERGS - Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0147840
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1843/65666
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLOS ONE
dc.rightsAcesso Aberto
dc.subjectCâncer
dc.subjectÁcido ribonucleico
dc.subject.otherMedullary thyroid carcinoma
dc.titleEffect of 3-UTR RET variants on RET mRNA secondary structure and disease presentation in medullary thyroid carcinoma
dc.typeArtigo de periódico
local.citation.epage15
local.citation.issue2
local.citation.spage1
local.citation.volume11
local.description.resumoThe RET S836S variant has been associated with early onset and increased risk for metastatic disease in medullary thyroid carcinoma (MTC). However, the mechanism by which this variant modulates MTC pathogenesis is still open to discuss. Of interest, strong linkage disequilibrium (LD) between RET S836S and 3'UTR variants has been reported in Hirschsprung's disease patients.
local.identifier.orcidhttps://orcid.org/0000-0001-6794-6042
local.identifier.orcidhttps://orcid.org/0000-0002-2935-1571
local.identifier.orcidhttps://orcid.org/0000-0002-4186-5532
local.identifier.orcidhttps://orcid.org/0000-0002-1999-9753
local.identifier.orcidhttps://orcid.org/0000-0002-9245-9315
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147840

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