Tumor necrosis factor-alpha in gingival crevicular fluid as a diagnostic marker for periodontal diseases: a systematic review

Página do item simplificado
dc.creatorTarcília Aparecida da Silva
dc.creatorDavidson Fróis Madureira
dc.creatorIzabella Lucas de Abreu Lima
dc.creatorGiselle Cabral da Costa
dc.creatorElizabeth Maria Bastos Lages
dc.creatorCarolina Castro Martins
dc.date.accessioned2025-04-04T19:14:50Z
dc.date.accessioned2025-09-08T22:48:44Z
dc.date.available2025-04-04T19:14:50Z
dc.date.issued2018-12
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.jebdp.2018.04.001
dc.identifier.issn1532-3390
dc.identifier.urihttps://hdl.handle.net/1843/81320
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of evidence based dental practice
dc.rightsAcesso Restrito
dc.subjectGingival crevicular fluid
dc.subjectPeriodontal diseases
dc.subjectTumor necrosis factor-alpha
dc.subjectBiomarkers, tumor
dc.subject.otherGingival crevicular fluid
dc.subject.otherPeriodontal disease
dc.subject.otherTumor necrosis factor-alpha
dc.titleTumor necrosis factor-alpha in gingival crevicular fluid as a diagnostic marker for periodontal diseases: a systematic review
dc.typeArtigo de periódico
local.citation.epage331
local.citation.issue4
local.citation.spage315
local.citation.volume18
local.description.resumoObjectives: The aim of this systematic review was to evaluate human gingival crevicular fluid (GCF) tumor necrosis factor-alpha (TNF-α) as a potential biomarker for diagnosis of periodontal disease (International prospective register of systematic reviews [PROSPERO] number: CRD42015020199). Methods: An electronic search for TNF-α in human GCF was conducted until May 17, 2018. Data from systemically healthy patients with healthy periodontium or periodontal disease were incorporated. Risk bias was assessed by Newcastle-Ottawa Scale for case-control studies and Jadad scale for clinical trials. Results: Twenty-six studies were included (12 case-control studies, 7 clinical trials, and 7 randomized controlled trials). Most case-control studies showed increased TNF-α concentration in GCF of patients with periodontal disease. The clinical trials and randomized controlled trials demonstrated no consistent modification of TNF-α level after periodontal intervention. Conclusion: The present data support the use of TNF-α in GCF as a potential biomarker for diagnosis of periodontal disease but not to monitor the healing after therapy.
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0009-0008-5510-5623
local.identifier.orcidhttps://orcid.org/0000-0002-7730-1587
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1532338217302531?via%3Dihub

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG