Antibacterial and cytotoxic activity of ruthenium-p-cymene complexes with 2-methylquinolin-8-ol derivatives

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dc.creatorAmalyn Nain-Perez
dc.creatorRené Csuk
dc.creatorLuiz Cláudio de Almeida Barbosa
dc.creatorMaria Helena Araujo
dc.creatorJoão Paulo Ataide Martins
dc.creatorJacqueline Aparecida Takahashi
dc.creatorGeane Oliveira
dc.creatorRenata Diniz
dc.creatorLucie Heller
dc.creatorSophie Hoenke
dc.date.accessioned2025-03-11T22:32:59Z
dc.date.accessioned2025-09-09T00:29:01Z
dc.date.available2025-03-11T22:32:59Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1002/slct.202100733
dc.identifier.issn2365-6549
dc.identifier.urihttps://hdl.handle.net/1843/80586
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofChemistrySelect
dc.rightsAcesso Restrito
dc.subjectAgentes antibacterianos
dc.subjectAgentes antineoplásicos
dc.subjectCitotoxidade de mediação celular
dc.subjectQuinoleina
dc.subjectRutenio
dc.subjectCompostos de rutenio
dc.subject.otherAntibacterial activity
dc.subject.otheranticancer agents
dc.subject.otherCytotoxicity
dc.subject.otherQuinoline synthesis
dc.subject.otherRuthenium
dc.titleAntibacterial and cytotoxic activity of ruthenium-p-cymene complexes with 2-methylquinolin-8-ol derivatives
dc.typeArtigo de periódico
local.citation.epage2950
local.citation.issue12
local.citation.spage2942
local.citation.volume6
local.description.resumoEight 5-aryl-2-methylquinolin-8-ol ligands (2–9) were prepared by a cross-coupling Suzuki reaction from precursors brominated at position 5 (10), and positions 5 and 7 (11). These ligands were converted into new ruthenium(II)-p-cymene complexes (12–22) (51–94 %). The cytotoxic and antimicrobial activities of all compounds were investigated. Ligands showed higher cytotoxicity (EC50=3.1–4.8 μM) than ruthenium complexes (EC50=5.2–7.8 μM) against human melanoma cancer cells (A375). The most potent compound 7 has been shown to act via apoptosis. Some compounds were more potent as anticancer than cisplatin. Several ruthenium complexes selectively inhibited S. typhimurium and S. aureus (IC50=4.64–146.15 and 9.37–125.95 μg/mL, respectively), while most ligands were potent against C. albicans. Molecular docking studies with a protein from S. aureus suggest four key amino acids interactions, in agreement with the inhibitory potential against this bacterium.
local.identifier.orcidhttps://orcid.org/0000-0002-5395-9608
local.identifier.orcidhttps://orcid.org/0000-0002-0784-0446
local.identifier.orcidhttps://orcid.org/0000-0001-7911-290X
local.identifier.orcidhttps://orcid.org/0000-0002-2609-0281
local.identifier.orcidhttps://orcid.org/0000-0002-1036-5965
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.identifier.orcidhttps://orcid.org/0000-0001-9042-9094
local.identifier.orcidhttps://orcid.org/0000-0002-6735-7026
local.identifier.orcidhttps://orcid.org/0000-0003-0596-5779
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202100733

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