Lack of association between denture trauma and loss of heterozygosity confronts the proposed pathologic role of chronic mucosal trauma in oral carcinogenesis

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dc.creatorVanessa de Fátima Bernardes
dc.creatorMarina Gonçalves Diniz
dc.creatorJéssica Carolina da Silva
dc.creatorDébora Chaves Moraes
dc.creatorLuiz Armando Cunha de Marco
dc.creatorCarolina Cavaliéri Gomes
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-08-06T17:51:38Z
dc.date.accessioned2025-09-09T01:30:18Z
dc.date.available2025-08-06T17:51:38Z
dc.date.issued2019-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1111/jop.12846
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/84114
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectLoss of heterozygosity
dc.subjectMouth neoplasms
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectCarcinogenesis
dc.subjectDental prosthesis
dc.subjectAssociation
dc.subjectElectrophoresis, capillary
dc.subjectChromosomes, human, pair 3
dc.subjectChromosomes, human, pair 9
dc.subjectChromosomes, human, pair 17
dc.subjectMucous membrane
dc.subject.otherDenture trauma
dc.subject.otherInflammatory fibrous hyperplasia
dc.subject.otherLoss of heterozygosity
dc.subject.otherOral cancer
dc.subject.otherOral squamous cell carcinoma
dc.titleLack of association between denture trauma and loss of heterozygosity confronts the proposed pathologic role of chronic mucosal trauma in oral carcinogenesis
dc.typeArtigo de periódico
local.citation.epage423
local.citation.issue5
local.citation.spage421
local.citation.volume48
local.description.resumoChronic mucosal trauma is suggested as an additional etiologic risk factor for oral squamous cell carcinoma (OSCC), but there is a lack of experimental-molecular data. If chronic trauma of the oral mucosa is carcinogenic, it should be associated with early genetic alterations seen during typical progression of OSCC, like loss of heterozygosity (LOH). We investigated LOH in the key chromosomal arms 3p, 9p and 17p in inflammatory fibrous hyperplasia associated with removable dental prosthesis and also in normal oral mucosa, by using the polymorphic microsatellite markers D3S1300 at 3p14.2, D9S1748 at 9p21, D17S1289 at 17p12 and D17S974 at 17p13 and capillary electrophoresis. LOH was detected in 2/15 (13%) fibrous hyperplasia samples similarly to other reactive and inflammatory lesions. None of the normal mucosa samples presented LOH. Our experimental-molecular results do not support the hypothesis that trauma associated with dental prosthesis has an important role in oral carcinogenesis.
local.identifier.orcidhttps://orcid.org/0000-0003-0194-7434
local.identifier.orcidhttps://orcid.org/0000-0002-4212-1172
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0003-2535-7439
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12846

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