Maytenus distichophylla and Salacia crassifolia: source of products with potential acetylcholinesterase inhibition

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dc.creatorFernanda L. Ferreira
dc.creatorVanessa G. Rodrigues
dc.creatorFernando C. Silva
dc.creatorBibiane L. G. Matildes
dc.creatorJacqueline Aparecida Takahashi
dc.creatorGracia D. F. Silva
dc.creatorLucienir P. Duarte
dc.creatorDjalma M. Oliveira
dc.creatorSidney A. V. Filho
dc.date.accessioned2023-10-09T23:18:26Z
dc.date.accessioned2025-09-08T22:58:11Z
dc.date.available2023-10-09T23:18:26Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.bjp.2016.12.006
dc.identifier.issn0102-695X
dc.identifier.urihttps://hdl.handle.net/1843/59341
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.rightsAcesso Aberto
dc.subjectProdutos naturais
dc.subjectFitoquímicos
dc.subject.otherCelastraceae
dc.subject.otherAcetylcholinesterase
dc.subject.otherNatural products
dc.subject.otherPentacyclic triterpenes
dc.subject.otherPhysostigmine
dc.titleMaytenus distichophylla and Salacia crassifolia: source of products with potential acetylcholinesterase inhibition
dc.typeArtigo de periódico
local.citation.epage474
local.citation.spage471
local.citation.volume27
local.description.resumoThe phytochemical study of the extract leaves from Maytenus distichophylla Mart. and Salacia crassifolia (Mart. ex Schult.) G. Don, Celastraceae, resulted in the isolation of 3-oxofriedelane, 3-hydroxyfriedelane, 3,24-dihydroxyfriedelane, 3-oxo-28,29-dihydroxyfriedelane, two mixtures of pentacyclic triterpenes (-amyrin with -amyrin and 3-stearyloxy-urs-12-ene with 3-stearyloxy-olean-12-ene), 3- palmityloxy-urs-12-ene, the steroid -sitosterol and its glycosylated derivative -glucosyl--sitosterol, tritriacontanoic acid and the natural polymer gutta percha. The chemical structures of these constituents were established by IR, 1H and 13C NMR spectral data. Crude extracts, the mixtures of triterpenes and the isolated constituents were subjected to in vitro acetylcholinesterase inhibitory evaluation. Acetylcholinesterase inhibitory effect was observed for crude chloroform extract leaves from M. distichophylla (100%) and S. crassifolia (97.93 ± 5.63%) and for the triterpenes 3,24-dihydroxyfriedelane (99.05 ± 1.12%), 3-oxo-28,29-dihydroxyfriedelane (90.59 ± 3.76%) and 3-palmityloxy-urs-12-ene (97.93 ± 1.47%). The percent inhibitions induced by these natural products were very similar to those produced by physostigmine (93.94 ± 2.10%) a standard acetylcholinesterase inhibitor. Therefore, these results open perspectives for the use of these species as source of compounds with similar physostigmine pharmacological effect.
local.identifier.orcidhttps://orcid.org/0000-0003-4651-3840
local.publisher.countryBrasil
local.publisher.departmentFAE - DEPARTAMENTO DE MÉTODOS E TÉCNICAS DE ENSINO
local.publisher.departmentFAE - FACULDADE DE EDUCAÇÃO
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0102695X1630206X?via%3Dihub

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