Overexpression of mutSα complex proteins predicts poor prognosis in oral squamous cell carcinoma

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dc.creatorVivian Petersen Wagner
dc.creatorLiana Preto Weber
dc.creatorGabriela Salvadori
dc.creatorLuize Meurer
dc.creatorFelipe Paiva Fonseca
dc.creatorRogério Moraes Castilho
dc.creatorCristiane Helena Squarize
dc.creatorPablo Agustin Vargas
dc.creatorManoela Domingues Martins
dc.date.accessioned2023-09-15T18:35:03Z
dc.date.accessioned2025-09-09T00:56:46Z
dc.date.available2023-09-15T18:35:03Z
dc.date.issued2016
dc.identifier.doihttps://doi.org/10.1097%2FMD.0000000000003725
dc.identifier.issn00257974
dc.identifier.urihttps://hdl.handle.net/1843/58729
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMedicine
dc.rightsAcesso Aberto
dc.subjectCarcinoma
dc.subjectProteins
dc.subjectLamins
dc.subjectDNA
dc.subjectDNA repair
dc.subject.otherfao clínica assunto carcinoma, proteina. busca dia 28 do 08 agosto ano 2023,
dc.titleOverexpression of mutSα complex proteins predicts poor prognosis in oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.issue22
local.citation.spagee3725
local.citation.volume95
local.description.resumoThe DNA mismatch repair (MMR) system is responsible for the detection and correction of errors created during DNA replication, thereby avoiding the incorporation of mutations in dividing cells. The prognostic value of alterations in MMR system has not previously been analyzed in oral squamous cell carcinoma (OSCC).The study comprised 115 cases of OSCC diagnosed between 1996 and 2010. The specimens collected were constructed into tissue microarray blocks. Immunohistochemical staining for MutSα complex proteins hMSH2 and hMSH6 was performed. The slides were subsequently scanned into high-resolution images, and nuclear staining of hMSH2 and hMSH6 was analyzed using the Nuclear V9 algorithm. Univariable and multivariable Cox proportional hazard regression models were performed to evaluate the prognostic value of hMSH2 and hMSH6 in OSCC.All cases in the present cohort were positive for hMSH2 and hMSH6 and a direct correlation was found between the expression of the proteins (P < 0.05). The mean number of positive cells for hMSH2 and hMSH6 was 64.44 ± 15.21 and 31.46 ± 22.38, respectively. These values were used as cutoff points to determine high protein expression. Cases with high expression of both proteins simultaneously were classified as having high MutSα complex expression. In the multivariable analysis, high expression of the MutSα complex was an independent prognostic factor for poor overall survival (hazard ratio: 2.75, P = 0.02).This study provides a first insight of the prognostic value of alterations in MMR system in OSCC. We found that MutSα complex may constitute a molecular marker for the poor prognosis of OSCC.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/md-journal/fulltext/2016/05310/overexpression_of_muts__complex_proteins_predicts.13.aspx

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