Complications and management of polymethylmethacrylate (pmma) injections to the midface

dc.creatorRoberto Murillolimongi
dc.creatorJeremiah Tao
dc.creatorAndré Borba
dc.creatorFilipe Pereira
dc.creatorAna Rosa Pimentel de Figueiredo
dc.creatorPatrícia Akaishi
dc.creatorAntônio Augusto Velasco e Cruz
dc.date.accessioned2023-06-05T19:50:48Z
dc.date.accessioned2025-09-09T00:31:25Z
dc.date.available2023-06-05T19:50:48Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doi10.1093/asj/sjv195
dc.identifier.issn1090820X
dc.identifier.urihttps://hdl.handle.net/1843/54522
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAesthetic Surgery Journal
dc.rightsAcesso Aberto
dc.subjectPolimetil Metacrilato
dc.subjectEfeitos Colaterais e Reações Adversas Relacionados a Medicamentos
dc.subjectInjeções
dc.subject.otherPolymethylmethacrylate
dc.subject.otherAdverse effects
dc.subject.otherInjections
dc.titleComplications and management of polymethylmethacrylate (pmma) injections to the midface
dc.typeArtigo de periódico
local.citation.epage135
local.citation.issue2
local.citation.spage132
local.citation.volume36
local.description.resumoBackground: Polymethylmethacrylate (PMMA) has been used as an injectable filler to treat hollows and reduce rhytids. PMMA injections have been associated with several side effects, however, the literature is scarce on periorbital complications and their treatments.Objectives: The purpose of this study is to report a series of complications after periorbital PMMA injections to the midface and to describe their management.Methods: Retrospective chart review, including photography and histopathology when available. Results: The authors identified 11 cases of complications of PMMA injections to the midface. Patient ages ranged from 36 to 62 years (mean, 47 years;median, 44 years). Two (18%) were males and 9 (82%) were females. Adverse effects began between 2 to 24 months after injection (mean, 7.2 months;median, 6 months). All patients had edema, erythema, and contour irregularity. Seven (64%) patients had nodules, 4 (36%) had yellow, xanthomatousskin changes, and 2 (18%) had eyelid malposition. Histopathology demonstrated a giant cell inflammation in 5 of 6 cases. Corticosteroid injection was tried in 6 cases but was associated with minimal clinical improvement. Surgical debulking of the implanted material was performed in 9 (82%) cases and was effective in improving edema, erythema, and nodularity.Conclusions: PMMA injection to the midface may be associated with chronic inflammation, fibrotic nodules, yellowing of the skin, and eyelid malposition. Intralesional corticosteroid injections yielded minimal or no improvement; surgical debulking achieved favorable results.
local.identifier.orcidhttps://orcid.org/0000-0002-7569-986X
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://doi:10.1093/asj/sjv195

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