Gingival crevicular fluid levels of human beta-defensin 1 in individuals with and without chronic periodontitis

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dc.creatorLidiane Cristina Machado Costa
dc.creatorDaniela Leal Zandim-Barcelos
dc.creatorJose Eustaquio da Costa
dc.creatorFernando de Oliveira Costa
dc.creatorLuis Otávio de Miranda Cota
dc.creatorSoldati
dc.creatorFonseca
dc.creatorAbreu
dc.date.accessioned2024-05-28T18:12:45Z
dc.date.accessioned2025-09-08T22:57:50Z
dc.date.available2024-05-28T18:12:45Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1111/jre.12558
dc.identifier.issn00223484
dc.identifier.urihttps://hdl.handle.net/1843/68752
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Periodontal Research
dc.rightsAcesso Restrito
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectBeta-defensins
dc.subjectChronic periodontitis
dc.subjectGingival crevicular fluid
dc.subjectGingiva
dc.subjectGingivitis
dc.subject.otherBeta-defensina
dc.subject.otherfluido gengival
dc.subject.otherPeriodontitis
dc.subject.otherELISA (enzyme-linked immunosorbent assay); beta-defensins; chronic periodontitis; gingival crevicular fluid.
dc.titleGingival crevicular fluid levels of human beta-defensin 1 in individuals with and without chronic periodontitis
dc.typeArtigo de periódico
local.citation.epage742
local.citation.issue5
local.citation.spage736
local.citation.volume53
local.description.resumoBackground and objective: Human beta-defensins (hBDs) contribute to innate immunity antimicrobial activity. They are also effective in the adaptive immune response and may play a crucial role in the susceptibility to diseases of the oral cavity. This study aimed to evaluate the levels of hBD-1 in the gingival crevicular fluid of individuals with and without chronic periodontitis. Material and methods: Twenty periodontally healthy individuals (H) and 20 individuals with chronic periodontitis were recruited. Gingival crevicular fluid samples were collected from: healthy sites (Hh) from periodontally healthy individuals; and healthy sites (Ph), sites with gingivitis (Pg), and sites with periodontitis (Pp) from individuals with periodontitis. The levels of hBD-1 (pg/mL) were measured using enzyme-linked immunosorbent assay. Comparisons of hBD-1 between individuals (H and chronic periodontitis) and among sites (Hh, Ph, Pg, Pp) were performed through hierarchical linear modeling. Results: Gingival crevicular fluid levels of hBD-1 were: Hh = 229.52 ± 138.96 (median 199.26), Ph = 53.88 ± 58.17 (median 35.75), Pg = 57.11 ± 40.18 (median 39.90) and Pp = 55.31 ± 37.28 (median 54.19). No influence of site diagnosis (level 1; health/gingivitis/periodontitis) was observed; however, individual diagnosis (level 2; health/periodontitis) influenced the levels of hBD-1 (P < .001). Conclusion: Periodontally healthy individuals showed higher gingival crevicular fluid levels of hBD-1 when compared to individuals with chronic periodontitis. This suggests a potential protective role of hBD-1 in the susceptibility to chronic periodontitis.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVA
local.publisher.departmentFAO - FACULDADE DE ODONTOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jre.12558

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