Curcumina e análagos sintéticos: possíveis suplementos alimentares para atuação em alterações oxidativas de diabéticos

Abstract

Reactive species are continually being produced by the body, but when they exceed the antioxidant defence capacity generate a condition known as oxidative stress, being related to several chronic diseases, such as diabetes mellitus (DM). Such disease is characterized by chronic hyperglycemia, resulting in metabolic imbalance and tissue damage. Thus, the appearance of such disease is highly correlated to population’s lifestyle and dietary habits, being of great interest the search for dietary supplements that may also act by preventing or decreasing oxidative changes in diabetic subjects. In this context, dietary supplements consisting of antioxidants are a very efficient protection to fight oxidative stress and, hence, diabetes and its complications. In this way, it stands out then, the well-known antioxidant activity shown by curcumin, as well asits synthetic analogues, has suggested these compounds to be used as promising dietary supplements, that would act as body protectors.