Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people

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dc.creatorArão Belitardo de Oliveira
dc.creatorMarco Túlio de Mello
dc.creatorSérgio Brasil Tufik
dc.creatorMário Fernando Prieto Peres
dc.date.accessioned2022-07-25T12:05:57Z
dc.date.accessioned2025-09-09T00:49:52Z
dc.date.available2022-07-25T12:05:57Z
dc.date.issued2019-03
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.physbeh.2018.12.018
dc.identifier.issn0031-9384
dc.identifier.urihttps://hdl.handle.net/1843/43576
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPhysiology and Behavior
dc.rightsAcesso Aberto
dc.subjectEndocanabinóides
dc.subjectPerda de peso
dc.subjectExercícios físicos
dc.subjectSaúde mental
dc.subjectConsumo de oxigênio
dc.subjectOxigênio / metabolismo
dc.subject.otherEndocannabinoids
dc.subject.otherWeight loss
dc.subject.otherPhysical activity
dc.subject.otherExercise
dc.subject.otherMental health
dc.subject.otherPeak oxygen uptake
dc.titleWeight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people
dc.typeArtigo de periódico
local.citation.epage197
local.citation.spage191
local.citation.volume201
local.description.resumoAnandamide, a major endocannabinoid, participates in energy metabolism homeostasis and neurobehavioral processes. In a secondary analysis of an open-label, randomized controlled trial, we investigated the long-term effect of aerobic exercise on resting plasma anandamide, and explored its relationship with changes in body weight, cardiorespiratory fitness, and mood status in healthy, physically inactive individuals. Participants recruited between March 2013 to August 2015 at the UNIFESP's Neurology/Psychobiology Department were randomly allocated into a 12-weeks supervised moderate exercise program, or into waitlist, control condition. Thirty-four participants (age = 38 ± 11.5, BMI = 26.6 ± 3.6) were intention to treat-analysed (Exercise: n = 17; Control: n = 17). After intervention, there were significant decreases in plasma anandamide (p < .01), anger, anxiety, and body weight (all p < .05), whereas cardiorespiratory fitness increased (p < .05) in the exercise group. There were no significant changes in any variable for the control group. In the whole cohort, adjusted R2 of multiple linear regressions showed that 12.2% of change body weight was explained by changes in anandamide (β = 0.391, p = .033), while 27% of change in mood disturbance (β = 0.546, p = .003), and 13.1% of change in anger (β = 0.404, p = .03) was explained by changes in anandamide. Our data suggest that the weight loss and mood improvement through regular moderate exercise may involve changes in anandamide metabolism/signaling. Trials registration: #NCT01972607.
local.identifier.orcidhttp://orcid.org/0000-0001-6408-0634
local.identifier.orcidhttps://orcid.org/ 0000-0003-3896-2208
local.identifier.orcidhttp://orcid.org/0000-0002-4012-4951
local.identifier.orcidhttp://orcid.org/0000-0002-0068-1905
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0031938418308254?via%3Dihub#!

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