Periodontal condition and levels of bacteria associated with periodontitis in individuals with bipolar affective disorders: a case-control study

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dc.creatorFabiano Araújo Cunha
dc.creatorLuís Otávio de Miranda Cota
dc.creatorSheila Cavalca Cortelli
dc.creatorTaís Browne de Miranda
dc.creatorFernando Silva Neves
dc.creatorJosé Roberto Cortelli
dc.creatorFernando de Oliveira Costa
dc.date.accessioned2025-07-09T20:53:38Z
dc.date.accessioned2025-09-09T00:39:18Z
dc.date.available2025-07-09T20:53:38Z
dc.date.issued2019-02
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jre.12605
dc.identifier.issn1600-0765
dc.identifier.urihttps://hdl.handle.net/1843/83465
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Periodontal Research
dc.rightsAcesso Restrito
dc.subjectEpidemiology
dc.subjectBipolar disorder
dc.subjectMicrobiology
dc.subjectPeriodontitis
dc.subjectPrevalence
dc.subjectDepression
dc.subjectAssociation
dc.subjectRisk
dc.subject.otherBipolar disorders
dc.subject.otherEpidemiology
dc.subject.otherMicrobiology
dc.subject.otherPeriodontitis
dc.titlePeriodontal condition and levels of bacteria associated with periodontitis in individuals with bipolar affective disorders: a case-control study
dc.typeArtigo de periódico
local.citation.epage72
local.citation.issue1
local.citation.spage63
local.citation.volume54
local.description.resumoObjective: To evaluate the epidemiological and microbiological aspects of the potential association between bipolar affective disorder (BAPD) and periodontitis. Methodology: The present case-control study comprised 176 individuals with BAPD and 176 controls. All individuals underwent a complete full-mouth periodontal examination and microbiological sampling. Data on bleeding on probing, probing depth, and clinical attachment level in all present teeth were recorded. Quantification of total bacterial load and Aggregatibacter actinomycetemcomitans, Treponema denticola, and Porphyromonas gingivalis counts were performed through qPCR. Data were analyzed using univariate analysis, Spearman correlation and multivariate logistic regression. Results: The prevalence of periodontitis was 39.7% among controls and 58.5% among individuals with BAPD (OR = 2.13; 95% CI 1.39-3.27). A. actinomycetemcomitans and P. gingivalis counts were significantly higher in individuals with BPAD and periodontitis. The final multivariate logistic regression revealed that periodontitis was strongly associated with the total bacterial load (OR = 1.91; 95% IC = 1.0-1.99; P < 0.001) and the depressive phase of BPAD (OR = 28.94; 95% IC = 4.44-177.27; P < 0.001). Conclusion: BAPD was associated with increased risk for periodontitis. Individuals with BPAD presented higher levels of A. actinomycetemcomitans and P. gingivalis, suggesting that periodontitis could be a co-morbidity frequently found in individuals with BAPD.
local.identifier.orcidhttps://orcid.org/0000-0003-0809-6935
local.identifier.orcidhttps://orcid.org/0000-0002-1141-8563
local.identifier.orcidhttps://orcid.org/0000-0002-7215-7029
local.identifier.orcidhttps://orcid.org/0000-0003-1517-5842
local.identifier.orcidhttps://orcid.org/0000-0001-5147-0705
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jre.12605

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