Role of salivary transcriptomics as potential biomarkers in oral cancer: a systematic review

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dc.creatorShankargouda Patil
dc.creatorGururaj Arakeri
dc.creatorAbdul Wahab Alamir
dc.creatorKamran Habib Awan
dc.creatorHosam Baeshen
dc.creatorMarco Ferrari
dc.creatorShekar Patil
dc.creatorFelipe Paiva Fonseca
dc.creatorPeter Brennan
dc.date.accessioned2023-11-21T20:50:19Z
dc.date.accessioned2025-09-09T00:30:15Z
dc.date.available2023-11-21T20:50:19Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.1111/jop.12895
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/61215
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectRNA
dc.subjectBiomarkers
dc.subjectSaliva
dc.subjectSystematic review
dc.subjectCarcinoma
dc.subjectDiagnosis
dc.subjectTherapeutics
dc.subject.otheracesso restrito revista Journal of oral pathology & medicine Role of salivary transcriptomics as potential biomarkers in oral cancer: a systematic review acesso restrito assunto RNA fao clínica busca dia 16 do 10 2023
dc.titleRole of salivary transcriptomics as potential biomarkers in oral cancer: a systematic review
dc.typeArtigo de periódico
local.citation.epage879
local.citation.issue10
local.citation.spage871
local.citation.volumeS
local.description.resumoIntroduction: Transcriptomes in saliva can be used as potential biomarkers for both diagnostic and response to treatment in oral squamous cell carcinoma (OSCC). In this review, we explored their application in this increasingly common disease. Materials and methods: PubMed, EMBASE, Scopus, Web of Science and grey literature from January 1990 to May 2017 were searched. Two independent reviewers performed the study selection according to eligibility criteria. Results: A total of nine studies were included. Three studies showed increased expression of DUSP1, IL8, IL1B, OAZ1, SAT1, S100P and two showed increased expression of miRNA-31 among study groups compared to normal healthy controls. The sensitivity ranged from 14% to 100%, while the specificity ranged from 38% to 100%. miRNA-27b had the highest AUC (write in full) of 0.9643 and DUSP1 had the minimum AUC of 0.41. Conclusion: Salivary transcriptomics may play an effective role as a robust and non-invasive biomarker sighting tool for the diagnosis and management of OSCC.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12895

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