Hydrophobic nanoprecipitates formed by benzoylphenylureas and β-cyclodextrin inclusion compounds: synthesis, characterization and toxicity against aedes aegypti larvae

Página do item simplificado
dc.creatorVanessa Cristina Estevam Bittencourt
dc.creatorAna Maria dos Santos Moreira
dc.creatorJeferson Gomes da Silva
dc.creatorAntônio Frederico de Freitas Gomides
dc.creatorCibele Velloso-Rodrigues
dc.creatorRegina Gendzzelevski Kelmann
dc.creatorLeonardo Meneghin Mendonça
dc.creatorIvana Silva Lula
dc.creatorÂngelo Márcio Leite Denadai
dc.date.accessioned2024-09-27T22:26:33Z
dc.date.accessioned2025-09-09T01:01:35Z
dc.date.available2024-09-27T22:26:33Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetos
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.heliyon.2019.e02013
dc.identifier.issn2405-8440
dc.identifier.urihttps://hdl.handle.net/1843/76997
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHelyon
dc.rightsAcesso Aberto
dc.subjectTermodinâmica
dc.subjectCiclodextrinas
dc.subjectLarva
dc.subjectAedes Aegypti
dc.titleHydrophobic nanoprecipitates formed by benzoylphenylureas and β-cyclodextrin inclusion compounds: synthesis, characterization and toxicity against aedes aegypti larvae
dc.typeArtigo de periódico
local.citation.epage12
local.citation.issue7
local.citation.spage1
local.citation.volume5
local.description.resumoThe aim of this work was to synthesize and characterize the inclusion compounds formed by the complexation of β-cyclodextrin (βCD) with insecticides from the class of benzoylphenylureas (BPUs), named novaluron (NOV) and diflubenzuron (DIF), beyond evaluate their larvicidal activity against Aedes aegypti larvae. Solid state characterization by FTIR showed changes in the main peaks of BPUs and βCD, suggesting the formation of inclusion compounds in solid phase. DTA and TGA thermal analysis showed changes in temperatures of BPUs decomposition as result of molecular interactions. 1H NMR experiments allowed to observe the occurrence of interactions in solution through changes in chemical shifts of BPUs aromatic hydrogens. However, the presence of H–H intermolecular correlations in 2D ROESY was found only for the DIF/βCD complex, suggesting different topology for each complex. Such hypothesis was corroborated by thermodynamic analysis using ITC, which showed different profile of titration curves, beyond endothermic and exothermic interactions for NOV/βCD and DIF/βCD complexes, respectively. DLS titrations of BPUs or BPUs/βCD DMSO solutions in aqueous solution demonstrated that the spontaneously formed hydrophobic nanoprecipitates (HNPs) have different profile of sizes depending on the BPU/βCD system, corroborating also with the hypothesis about the existence of different topologies for each complex. Finally, the HNPs of inclusion compounds showed to be more efficient than free BPUs, allowing proposing a new insecticide formulation.
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2405844019356695?via%3Dihub

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Hydrophobic nanoprecipitates formed by benzoylphenylureas and β-cyclodextrin inclusion compounds- synthesis, characterization and toxicity against aedes aegypti larvae.pdf
Tamanho:
3.15 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG