Explorando a relação entre transtorno depressivo, sono e fator neurotrófico derivado do cérebro: uma revisão integrativa

Abstract

Depression is considered a common but worrying disorder, which has significant impacts on sleep, cognition and appetite and affects daily tasks, work capacity, socioeconomic status and quality of life. Given that there is scientific evidence of a correlation between sleep, BDNF and depression, a systematic literature review was carried out on the subject. We used scientific articles in English, published in the PUBMED databases, which met the previously defined inclusion and exclusion criteria. During the research, it was found that the various articles analyzed provided a comprehensive view of the interrelationships between depression, BDNF and sleep, highlighting their relevance in understanding major depressive disorder. From these results, it can be concluded that although evidence suggests an association between lower baseline levels of BDNF in depressed patients, their link with symptom severity and possible implications for the neuroimmune profile and cognitive decline, we still lack a definitive causal relationship. There is an urgent need for more comprehensive studies, with more representative samples, to validate and deepen these initial findings, in addition to exploring the role of the Val66met polymorphism and the usefulness of sleep and BDNF as biomarkers for more effective treatment of depressive symptoms.