Azithromycin for the treatment of eosinophilic nasal polyposis: clinical and histologic analysis

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dc.creatorIsamara Simasde Oliveira
dc.creatorPaulo Fernando Tormin Borges Crosara
dc.creatorGeovanni Dantas Cassali
dc.creatorDiego Carlos Dos Reis
dc.creatorDanilo Santana Rodrigues
dc.creatorFlavio Barbosa Nunes
dc.creatorRoberto Eustáquio Santos Guimarães
dc.date.accessioned2023-07-10T19:30:15Z
dc.date.accessioned2025-09-09T00:42:45Z
dc.date.available2023-07-10T19:30:15Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.2500/ar.2016.7.0160
dc.identifier.issn21526575
dc.identifier.urihttps://hdl.handle.net/1843/56036
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofTherapeutic Advances in Allergy and Rhinology
dc.rightsAcesso Aberto
dc.subjectMacrolídeos
dc.subjectPólipos nasais
dc.subjectAzitromicina
dc.subjectEosinófilos
dc.subject.otherMacrolides
dc.subject.otherNasal polyps
dc.subject.otherAzithromycin
dc.subject.otherEosinophils
dc.titleAzithromycin for the treatment of eosinophilic nasal polyposis: clinical and histologic analysis
dc.typeArtigo de periódico
local.citation.epage61
local.citation.issue2
local.citation.spage55
local.citation.volume7
local.description.resumoIntroduction: Macrolides used as immunomodulators are a promising tool for chronic inflammatory airway diseases.Eosinophilic nasal polyposis (ENP) is still considered a disease that is difficult to control with the currently standardized treatments.Objectives: To evaluate prolonged treatment with low-dose azithromycin for ENP based on clinical and histopathologic variables.Methods: The present investigation was a self-paired case study of 33 patients with ENP. A comparison was performed between patients before and after treatment with azithromycin for 8 weeks. The patients were subjected to clinical examinations,staging (three-dimensional imaging by endoscopy), application of the questionnaire, and biopsy of nasal polyps at the beginning and at the end of the treatment. Results: The treatment yielded a clinical improvement regarding the two variables studied: polyposis staging (69.7%) and questionnaire (57.6%). We did not find significant differences in the inflammatory pattern and in the percentage or absolute number of eosinophils per field between samples obtained before and after the treatment (p > 0.05). There was no difference between the answers obtained from groups with and without asthma and/or aspirin intolerance (p>0.3). The patients with advanced initial staging exhibited lower subjective improvement index and staging reduction (p> 0.031 and p > 0.012, respectively). Conclusion: Based on this study, azithromycin may be considered as another therapeutic option for ENP. However, further studies are necessary to define the real mechanism of action involved.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/full/10.2500/ar.2016.7.0160?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

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