Comparison of survival outcomes between ameloblastic carcinoma and metastasizing ameloblastoma: A systematic review

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dc.creatorBruno Ramos Chrcanovic
dc.creatorRoberta Rayra Martins-Chaves
dc.creatorFlávia Sirotheau Correa Pontes
dc.creatorFelipe Paiva Fonseca
dc.creatorRicardo Santiago Gomez
dc.creatorHélder Antônio Rebelo Pontes
dc.date.accessioned2023-11-16T21:17:50Z
dc.date.accessioned2025-09-09T00:37:12Z
dc.date.available2023-11-16T21:17:50Z
dc.date.issued2022-07-13
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.13334
dc.identifier.urihttps://hdl.handle.net/1843/61013
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Aberto
dc.rightsAtribuição-NãoComercial-SemDerivados 3.0 Portugal
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pt/
dc.subjectCarcinoma
dc.subjectAmeloblastoma
dc.subjectNeoplasias
dc.subject.otherAmeloblastic carcinoma
dc.subject.otherClinical features
dc.subject.otherMetastasizing ameloblastoma
dc.subject.otherOdontogenic tumors
dc.subject.otherRecurrence
dc.titleComparison of survival outcomes between ameloblastic carcinoma and metastasizing ameloblastoma: A systematic review
dc.typeArtigo de periódico
local.citation.epage610
local.citation.issue7
local.citation.spage603
local.citation.volume51
local.description.resumoPurpose To investigate and compare the demographic data, occurrence of recurrence and metastasis, and survival prognosis between ameloblastic carcinoma (AC) and metastasizing ameloblastoma (MA), based on appropriate and currently accepted eligible diagnostic criteria, in a systematic review of the literature. Methods An electronic search was undertaken, last updated in December 2021. Eligibility criteria included publications having enough clinicopathological information to confirm the diagnosis of these tumors. Results Seventy-seven publications reporting 85 ACs and 43 MAs were included. Both tumors were more frequent in mandible and showed different clinical profiles regarding patients' sex and age. There was no difference in the estimated cumulative survival between patients diagnosed with these tumors. Metastases mainly affected the lungs, followed by cervical lymph nodes. The mean time between the first metastasis and the last follow-up was higher for MA (p = 0.021). In addition, MA patients remained alive longer than AC patients after the first metastasis diagnosis (p = 0.041). Considering only the cases that metastasized, a higher ratio of AC patients died in comparison to MA patients (p = 0.003). The occurrence of recurrence was associated with a conservative primary treatment with both AC (p < 0.001) and MA tumors (p = 0.017). Multiple recurrent events were associated with conservative primary therapies with MA (p < 0.001) but not with AC (p = 0.121). Conclusion In addition to some demographic differences, ACs that metastasize present a worse prognosis than MA. As conservative procedures are associated with multiple recurrent events, this treatment modality should be avoided for both tumors.
local.identifier.orcidhttps://orcid.org/0000-0002-3460-3374
local.identifier.orcidhttps://orcid.org/0000-0002-6657-4547
local.identifier.orcidhttps://orcid.org/0000-0002-7609-8804
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13334

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